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Application of tea saponin in preparation of medicine used for preventing or treating depression

A technology of tea saponin and depression, applied in the field of medicine, can solve problems such as undiscovered tea saponin

Active Publication Date: 2020-11-24
中国医科大学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is currently no technical report on the use of tea saponin in the field of depression treatment.

Method used

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  • Application of tea saponin in preparation of medicine used for preventing or treating depression
  • Application of tea saponin in preparation of medicine used for preventing or treating depression
  • Application of tea saponin in preparation of medicine used for preventing or treating depression

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Embodiment Construction

[0023] The technical solutions and technical effects of the present invention will be described in detail below in conjunction with specific embodiments and accompanying drawings. Experimental methods that do not indicate specific conditions are usually based on conventional conditions, such as the conditions described in textbooks and experimental guidelines, or according to the conditions suggested by the manufacturer, which are well known or easily known to those of ordinary skill in the art. The following examples are only The preferred embodiments of the present invention do not limit the present invention. For those skilled in the art, the present invention can have various modifications and changes, and within the spirit and principles of the present invention, any modifications and equivalent replacements made , improvements, etc., should be included within the protection scope of the present invention. The tea saponin (Tea Saponin) that embodiment is used is purchased...

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Abstract

The invention belongs to the technical field of medicines, and relates to an application of tea saponin, specifically to the application of the tea saponin in preparation of a medicine used for preventing or treating depression. According to the invention, research results discover that the tea saponin can obviously improve depression behaviors (including sweet water, forced swimming and tail suspension) of CMUS model mice and anxiety behaviors (an open field) frequently accompanied by depression, so statistical significance is achieved. Meanwhile, the tea saponin can enhance the expression ofBDNF, which proves that the tea saponin plays an antidepressant role by up-regulating the expression of BDNF; and the action strength of the tea saponin is similar to the action strength of fluoxetine, so the tea saponin can be used for preparing the medicine used for preventing or treating depression. The tea saponin belongs to natural components; and the medicine prepared from the tea saponin does not cause serious side effects, is safe to take, can solve the problem of treating depression, and provides a novel treatment medicine for treating depression.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to the application of tea saponin, in particular to the application of tea saponin in the preparation of drugs for preventing or treating depression. Background technique [0002] Depression is a mood disorder characterized by significant and persistent depression as the main clinical manifestation. Its incidence rate is increasing year by year, causing a certain burden to patients' families and society. The pathogenesis of depression has not yet been elucidated. At present, the main mechanism of action of first-line antidepressants is to regulate the level of monoamine neurotransmitters in the brain, but only about 1 / 3 of the patients have significant improvement in their depressive symptoms after medication. Moreover, antidepressants take a long time to take effect and have obvious side effects. Common side effects include serum toxicity, manifesting mania, restlessness, insomnia...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61K36/82A61P25/24A61P25/22
CPCA61K31/704A61K36/82A61P25/24A61P25/22
Inventor 谷莉孙凯丽宋丹张熠超
Owner 中国医科大学
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