14results about How to "Improve anxiety" patented technology

The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for tonifying qi and blood and treating hypomenorrhea caused by deficiency of qi and blood and a preparation method thereof. The composition is prepared by carefully selecting a plurality of traditional Chinese medicinal materials with the effects of tonifying qi and blood, regulating menstruation and nourishing blood and combining the traditional Chinese medicinal materials according to a specific proportion, and comprises ginseng, codonopsis pilosula, lucid ganoderma, astragalus membranaceus, angelica sinensis, peach kernels, donkey-hide gelatin, longan aril, Chinese dates, Chinese yams, radix polygonati officinalis, fructus lycii, poria cocos, roses and pericarpium citri reticulatae. The traditional Chinese medicine composition is prepared through the processes of extraction, double-effect concentration, filtration, blending and the like through scientific proportioning and a unique processing technology, aims to effectively improve the symptom of scanty menstruation caused by deficiency of qi and blood of women, recover normal menstruation, condition the body and improve the overall health level, has good safety and effectiveness, and is worthy of popularization and application. And a new choice is provided for health management of women. The traditional Chinese medicine composition for tonifying qi and blood and treating hypomenorrhea caused by deficiency of qi and blood is safe, small in side effect, efficient, convenient and good in taste.

The invention discloses a series of homocysteine responsive removal systems. The homocysteine responsive removal systems are obtained by carrying out a Schiff base reaction on a substance containing cystamine and / or selenocystamine and a multi-aldehyde monomer. A series of homocysteine responsive removal systems have high stability, can be uniformly and stably dispersed in an aqueous solution, and can specifically remove highly expressed homocysteine in depression patients, so that rapid and stable removal of blood risk factors is realized. According to the invention, a rapid, efficient and specific homocysteine removal effect is shown, and meanwhile, excellent biological safety is kept, which is crucial for ensuring the safety of a patient in a treatment process. Therefore, the COFs-based homocysteine responsive removal system is expected to become a novel efficient treatment means for treating homocysteine related diseases such as depression and the like, and revolutionary transformation is brought to research and clinical practice in related fields.

The invention discloses a magnesium boride nanosheet / inulin composite hydrogel and application thereof in treating inflammatory bowel diseases and complicated mental diseases, and the composite hydrogel is synthesized by doping magnesium boride nanosheets into inulin and carrying out hot melting and cooling to form gel. The composite hydrogel has good oxidation resistance and biocompatibility, reducing hydrogen can be generated through a hydrolysis reaction to be used for reducing active oxygen and inflammatory factors of the enteritis part, intestinal flora can be adjusted, meanwhile, the composite hydrogel can be prevented from being affected by gastric acid and reach the intestinal part through the addition of inulin, and the enteritis treatment effect is improved. Therefore, the inflammatory bowel disease and related anxiety and depression symptoms thereof are effectively treated.

The invention belongs to the technical field of biological medicine, and particularly provides application of EAAT2 as a drug target to screening of drugs for improving anxiety disorder. The drug target EAAT2 is mainly expressed on astrocytes, the research finds that the expression level of the EAAT2 is closely related to the anxiety state, and the anxiety disorder can be improved by regulating and controlling the target through a specific compound and a specific adenovirus vector. A brand-new drug target and a new treatment means and thought are provided for treatment of anxiety disorder and drug research and development.

The invention discloses composite soothing essential oil and a use method thereof, and belongs to the technical field of essential oil blending and application. The compound soothing essential oil is characterized in that an essential oil mixed solution comprises the following single essential oil in parts by volume: 5-20 parts of holly, 5-20 parts of peppermint, 5-20 parts of cananga odorata, 5-10 parts of camphor tree, 5-10 parts of German chamomile, 1-5 parts of blue wormwood, 1-5 parts of permanent flower, 1-5 parts of sweet-scented osmanthus and 1-5 parts of yarrow. According to the compound soothing essential oil disclosed by the invention, various single plant essential oil with good effects of relieving anxiety mood and tranquilizing and allaying excitement is organically blended and combined according to an active component and aroma compatibility principle, so that the compound soothing essential oil is prepared. All the components of the prepared compound soothing essential oil have a synergistic effect, and the compound soothing essential oil has good effects in the aspects of improving anxiety, regulating decompression, eliminating anxiety, calming and resisting depression. The composition is simple and convenient to use and obvious in effect, has an obvious anti-anxiety effect through sniffing intake, can relieve anxiety-like behaviors of mice, and provides a new effective method for preventing and relieving anxiety disorder.

The invention discloses a PDCD4 inhibitor based on PROTAC modification and application of the PDCD4 inhibitor in preparation of antidepressant drugs, a series of PROTAC modified compounds with a protein degradation function are successfully synthesized by performing PROTAC modification on a small molecule compound ZINC20031600, combining E3 ligase ligands CRBN and VHL and using PEG with different lengths as linkers. On the basis of the prior art, the protein degradation efficiency and selectivity of PROTAC molecules are remarkably improved, the cytotoxicity is reduced, and good clinical application potential and market prospects are achieved.

The application provides a lactobacillus plantarum HLP0107 and application of the strain or a fermentation product thereof in preventing and / or improving depression and anxiety.

The invention discloses a traditional Chinese medicine decoction for treating insomnia and a preparation method of the traditional Chinese medicine decoction, and relates to the technical field of traditional Chinese medicine decoction, the traditional Chinese medicine decoction is prepared from a traditional Chinese medicine composition, and the traditional Chinese medicine composition is prepared from 3-8 g of cassia twig, 4-9 g of liquorice, 25-35 g of dragon bone, 25-35 g of oyster, 10-20 g of semen cuscutae, 10-20 g of morinda officinalis, 10-20 g of poria with hostwood and 5-15 g of polygala tenuifolia. The traditional Chinese medicine decoction has the effects of regulating the heart and kidney, regulating yin and yang, and calming the heart and tranquilizing the mind, can shorten the sleeping time, prolong the sleeping time and improve the sleeping quality of a heart-yang deficiency type insomnia patient, and provides a new idea and an effective prescription for treating the insomnia by the traditional Chinese medicine.

The embodiment of the invention discloses a traditional Chinese medicine compound preparation for treating anxiety, depression and insomnia of young and middle-aged women and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. Comprising the following raw materials: 15-25 parts of radix rehmanniae preparata, 10-15 parts of angelica sinensis, 13-17 parts of radix paeoniae alba, 13-17 parts of spina date seed, 10-15 parts of ligusticum wallichii, 10-15 parts of pawpaw, 10-15 parts of lily, 7-11 parts of platycladi seed, 7-11 parts of fructus aurantii, 7-11 parts of gardenia, 7-11 parts of perilla stem, 7-11 parts of poria cocos, 13-17 parts of oyster and 7-11 parts of liquorice. The traditional Chinese medicine compound preparation has the effects of enhancing memory and improving anxiety, depression and sleep quality, is reasonable in compatibility through research on all the raw materials, achieves a synergistic effect among all the raw materials, is convenient to use, good in taste, easy to absorb, free of toxic and side effects and addiction, is especially suitable for middle-aged and young female patients to take, and has a wide application prospect. The raw materials are wide in source, low in cost and high in safety.

The invention discloses application of bifidobacterium breve NX-5 in preparation of drugs for relieving anxiety and improving sleep, and belongs to the technical field of microorganisms. The invention discloses application of bifidobacterium breve NX-5 in preparation of drugs for relieving anxiety and improving sleep, a bacterial suspension of the bifidobacterium breve NX-5 can significantly reduce the movement distance, mania time and active time of zebra fish in an in-vivo insomnia model, and significantly increase the standing time, and has the potential of being applied in vivo to relieve anxiety and improve sleep. The bifidobacterium breve NX-5 disclosed by the invention has a huge potential application prospect in the aspects of relieving anxiety and improving sleep.

The invention discloses a new application of montmorillonite powder, and belongs to the technical field of biological medicines. The montmorillonite powder has a huge specific surface area, a unique pore structure and rich non-uniform charges, can cover gastrointestinal mucosa and adsorb and isolate harmful bacteria, pathogens and the like after being orally taken, only plays a role on the surface of the mucosa, cannot be absorbed by a human body, and is finally discharged out of the body together with harmful substances along with intestinal peristalsis, so that the treatment effect is good. The montmorillonite powder is used for resisting anxiety and improving sleep quality, and after the montmorillonite powder is orally taken, the montmorillonite powder has the effects of obviously improving anxiety and improving sleep quality and is relatively small in side effect.

The invention provides a compound probiotic with the effects of soothing the nerves and helping sleep and application of the compound probiotic. The compound probiotic comprises lactobacillus plantarum ZQ15 (the preservation number is CGMCC (China General Microbiological Culture Collection Center) NO.30265) and lactobacillus rhamnosus AlcoKer0067 (the preservation number is CGMCC NO.31221). The invention further provides a preparation method of the compound probiotic. Research finds that the lactobacillus plantarum ZQ15 and the lactobacillus rhamnosus AlcoKer0067 form a compound probiotic (or a compound probiotic microbial agent), the two bacteria are compounded and can be mutually matched and promoted, and when the lactobacillus plantarum ZQ15 and the lactobacillus rhamnosus AlcoKer0067 are applied to preparation of the nerve soothing and sleep aiding product, the generation of 5-HT and GABA can be remarkably promoted, and the effects of relieving anxiety, soothing the nerves and aiding sleep are enhanced. The compound probiotics composed of lactobacillus plantarum ZQ15 and lactobacillus rhamnosus AlcoKer0067 further form a composition with traditional Chinese medicine extracts, prebiotics, small molecule peptides and the like, the content of 5-HT and GABA in blood of mice can be obviously increased, and the effect is most remarkable after the compound probiotics, the traditional Chinese medicine extracts, the prebiotics, the small molecule peptides and the like are combined for administration.

The invention discloses a green field Xianxi incense. The green field Xianxi incense comprises abelmoschus esculentus seeds, sea salt and salvia officinalis. The light wave healing bed has multiple curative effects, natural incense is fused with music, and particularly the natural incense has treatment and health care potential. The abelmoschus esculentus seeds have the effects of relieving pressure and anxiety and can help the user relax the mind and body and relieve the pressure. The sea salt is rich in mineral substances, and is beneficial to relieving muscle tension and promoting body relaxation. Salvia officinalis has calming and relaxing effects, can relieve pressure and anxiety emotion, and is especially suitable for relieving pressure and anxiety emotion of teenagers.

The invention discloses a soft capsule for improving an anxiety state as well as a preparation method and application of the soft capsule, and belongs to the technical field of pharmaceutical preparations. Comprising contents and a capsule shell wrapping the contents. The content consists of a compound extract, phospholipid and emotional fish oil. The compound extract is prepared from bupleurum chinense, salvia miltiorrhiza, cape jasmine, angelica sinensis, bighead atractylodes rhizome, poria cocos, dried ginger, mint and liquorice; the capsule shell comprises chitosan, sodium alginate, a rosemary extract microcapsule, vitamin C palmitate, titanium dioxide, pachymaran and the like, and the rosemary extract microcapsule is prepared from a rosemary extract through pachymaran microencapsulation. Through the synergistic effect of all the components, the compatibility of the compound extract and the emotional fish oil is effectively improved, the stability of an oil phase system is improved, the oxidative rancidity risk of the emotional fish oil is reduced, meanwhile, the emotional fish oil is matched with the gastrointestinal absorption characteristics of people with weakness of the spleen and the stomach, and a pharmaceutical preparation choice is provided for conditioning the anxiety state.