86results about How to "Improve anxiety" patented technology

The invention discloses a traditional Chinese medicine extract with the anti-depression effect as well as a preparation method and application thereof. The preparation method comprises the steps thatradix bupleuri, Chinese angelicas, rhizoma atractylodis macrocephalae stir-fried with bran, white paeony roots, herba menthae and honey-fried licorice roots are taken according to the component ratio,60-90% ethanol of 6-10 times is added for extraction twice, extraction is carried out for 1-3 hours each time, filtering is carried out, and filtrates are combined and concentrated so as to obtain ethanol extraction clear paste; and water of 6-10 times are added into medicine residues for extraction twice, extraction is carried out for 1-3 hours each time, filtering is carried out, and filtratesare combined and concentrated so as to obtain water extraction clear paste, the ethanol is added into the water extraction clear paste so as to enable the ethanol content to reach 60-80%, standing iscarried out for 24 hours, and supernate is taken and concentrated so as to obtain clear paste; and the clear paste and the ethanol extraction clear paste are combined, are uniformly mixed and then areconcentrated so as to obtain thick paste, microwave decompression drying is carried out, crushing is carried out, and sieving is carried out through a 80-mesh sieve so as to obtain the traditional Chinese medicine extract. On the basis of having an exact anti-depression effect, the extract also has two novel anti-depression effect characteristics and can be applied to preparation of medicines fortreating depression.

The invention provides application of a substituted cinnamamide derivative to preparation of anxiolytic medicine. The substituted cinnamamide derivative uses a compound of a structure shown by a formula (I) or a pharmaceutically acceptable salt as a medicine active ingredient. The concrete formula is shown as the accompanying drawing; in the formula, R1 is -H, -OH, -F, -Cl, -Br, -I, -OCH3, -OCF3, -OCHF2, -OCH2F, -CF3, -CHF2, -CH2F, -CH3, -CH3CH2, -CF3CH2, -CN, -NO2, -NH2 or -COOR5; R2 is H, C1-C10 straight-chain alkyls, C3-C10 branch-chain alkyl groups, C3-C10 cyclic hydrocarbon groups, C1-C10 hydroxyalkyls or N-substituted piperazine derivative groups; or the R2 is a group forming a nafoxidine group, a piperidyl or a cyclohexylamine group with the adjacent X. The formula (I) is shown as the accompanying drawing.

Methods for diagnosing a scoliosis (e.g., adolescent idiopathic scoliosis (AIS)) and / or a predisposition to developing a scoliosis based on the determination of the variation of osteopontin (OPN) levels induced by mechanical forces / stimuli are described.