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Traditional Chinese medicine extract with anti-depression effect as well as preparation method and application thereof

An extract and antidepressant technology, applied in the field of traditional Chinese medicine extract with antidepressant effect and its preparation, can solve the problems of poor process controllability, difficult quality control, large dosage, etc., achieve controllable quality, improve learning and memory Decreased ability and anxiety, the effect of reasonable and safe process

Inactive Publication Date: 2018-10-16
SHANXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the early stage, two authorized patents (201010110283.7 and 201110084715.6) of our research group were extracted with ethyl acetate and petroleum ether, showing that Xiaoyao Powder has a clear antidepressant effect, but on the one hand, industrial production has many safety hazards, and the process controllability is poor; The original prescription of Xiaoyao San has many medicinal materials, the dosage is relatively large, and the quality is not easy to control

Method used

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  • Traditional Chinese medicine extract with anti-depression effect as well as preparation method and application thereof
  • Traditional Chinese medicine extract with anti-depression effect as well as preparation method and application thereof
  • Traditional Chinese medicine extract with anti-depression effect as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Weigh 30 parts of Bupleurum bupleuri, 30 parts of angelica, 30 parts of bran-fried Atractylodes macrocephala, 30 parts of white peony, 10 parts of mint, and 15 parts of roasted licorice, add 8 times the weight of 75% ethanol to extract twice, each time 2h , filtered, combined filtrate, concentrated to the alcohol extraction paste with a relative density of 1.09; the dregs were extracted 2 times by adding 8 times the weight of water, each 2h, filtered, combined with the filtrate, concentrated to a relative density of 1.09 water extracted Clear paste; add ethanol to the water-extracted clear paste to make the alcohol content reach 70%, let it stand for 24 hours (4°C), take the supernatant and concentrate it to a clear paste with a relative density of 1.09, combine it with the alcohol-extracted clear paste, and mix well Afterwards, it is concentrated to a thick paste with a relative density of 1.25, dried under reduced pressure by microwave to obtain a dry extract, crushed,...

Embodiment 2

[0025] Weigh 30 parts of Bupleurum bupleuri, 30 parts of angelica, 20 parts of bran-fried Atractylodes macrocephala, 20 parts of white peony, 10 parts of mint, and 15 parts of roasted licorice, add 8 times the weight of 60% ethanol to extract twice, each time 2h , filtered, combined filtrate, concentrated to the alcohol extraction paste with a relative density of 1.08; the dregs were extracted 2 times by adding 8 times the weight of water, each 2h, filtered, combined with the filtrate, concentrated to a relative density of 1.08 water extracted Clear paste; add ethanol to the water-extracted clear paste to make the alcohol content reach 60%, let it stand for 24 hours (4°C), take the supernatant and concentrate it to a clear paste with a relative density of 1.08, combine it with the alcohol-extracted clear paste, and mix well Afterwards, it is concentrated to a thick paste with a relative density of 1.24, dried under reduced pressure by microwave to obtain a dry extract, crushed,...

Embodiment 3

[0027] Weigh 30 parts of Bupleurum bupleuri, 30 parts of angelica, 30 parts of bran-fried Atractylodes macrocephala, 20 parts of white peony, 10 parts of mint, and 15 parts of roasted licorice, add 8 times the weight of 90% ethanol to extract twice, each time 2h , filtered, combined filtrate, concentrated to the alcohol extraction paste with a relative density of 1.10; the dregs were extracted 2 times by adding 8 times the weight of water, each time for 2 hours, filtered, combined with the filtrate, concentrated to a relative density of 1.10. Clear paste; add ethanol to the water-extracted clear paste to make the alcohol content reach 80%, let it stand for 24 hours (4°C), take the supernatant and concentrate it to a clear paste with a relative density of 1.10, combine it with the alcohol-extracted clear paste, and mix well Afterwards, it is concentrated to a thick paste with a relative density of 1.26, dried under reduced pressure by microwave to obtain a dry extract, crushed, ...

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Abstract

The invention discloses a traditional Chinese medicine extract with the anti-depression effect as well as a preparation method and application thereof. The preparation method comprises the steps thatradix bupleuri, Chinese angelicas, rhizoma atractylodis macrocephalae stir-fried with bran, white paeony roots, herba menthae and honey-fried licorice roots are taken according to the component ratio,60-90% ethanol of 6-10 times is added for extraction twice, extraction is carried out for 1-3 hours each time, filtering is carried out, and filtrates are combined and concentrated so as to obtain ethanol extraction clear paste; and water of 6-10 times are added into medicine residues for extraction twice, extraction is carried out for 1-3 hours each time, filtering is carried out, and filtratesare combined and concentrated so as to obtain water extraction clear paste, the ethanol is added into the water extraction clear paste so as to enable the ethanol content to reach 60-80%, standing iscarried out for 24 hours, and supernate is taken and concentrated so as to obtain clear paste; and the clear paste and the ethanol extraction clear paste are combined, are uniformly mixed and then areconcentrated so as to obtain thick paste, microwave decompression drying is carried out, crushing is carried out, and sieving is carried out through a 80-mesh sieve so as to obtain the traditional Chinese medicine extract. On the basis of having an exact anti-depression effect, the extract also has two novel anti-depression effect characteristics and can be applied to preparation of medicines fortreating depression.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine extraction, and in particular relates to a traditional Chinese medicine extract with antidepressant effect and its preparation method and application. Background technique [0002] At present, there are three main ways to treat depression: drug therapy, psychotherapy and physical therapy, but chemical drug therapy is still the main method. The types of antidepressant drugs on the market are limited, the mechanism is single, the effective rate is not high, not more than 70%, and the side effects are relatively large, such as constipation, decreased libido, etc., which threaten the health of other body functions of patients while treating depression. Clinically, when choosing Western medicine to treat depression, factors such as treatment efficiency, mechanism of action, dosage, side effects, and drug interactions should be considered comprehensively, and for some complex depressions such...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61K36/65A61P25/24
CPCA61K36/232A61K36/233A61K36/284A61K36/484A61K36/534A61K36/65A61K36/71A61P25/24A61K2300/00
Inventor 秦雪梅赵玉娇田俊生张潇杜冠华
Owner SHANXI UNIV
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