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41 results about "Idiopathic scoliosis" patented technology

Idiopathic scoliosis. an abnormal condition characterized by a lateral curvature of the spine. It is the most common type of scoliosis, evident in 70% of all patients with scoliosis and up to 80% of those with structural scoliosis. It may occur at any age, but three types are commonly associated with certain age groups.

Device for providing a combination of flexibility and variable force to the spinal column for the treatment of scoliosis

Non-surgical treatments for idiopathic scoliosis include muscle stimulation therapy, chiropractic care, and the application of a variety of braces (orthotics). Surgical intervention frequently employs rigid metallic braces that prevent further flexing of the spine where applied. This invention allows flexing of the spine with long term correction of the scoliosis by application of small variable forces to supplant and counter the unbalance of the pertinent muscles. This invention may be applied to other spine problems in addition to idiopathic scoliosis as this invention permits and accommodates flexing of the spine and simultaneously supplies correcting and straightening forces.
Owner:LEWIS DAVID WARREN

Implant for treating idiopathic scoliosis and a method for using the same

The present invention concerns implant for treating rotational malfunction of the spinal column comprising a linear plate, a set of retractors and clasping means. The present invention further concerns a method for treating Scoliosis by the implantation of said implant
Owner:HADASIT MEDICAL RES SERVICES & DEVMENT

Data processing method for idiopathic scoliosis images

The invention relates to a data processing method for idiopathic scoliosis images, including the following steps: (a) importing an idiopathic scoliosis image to a data processing center; (b) identifying the imported image; (c) measuring the predetermined parameters of the identified image to obtain a set of data values; and (d) processing and outputting the data values obtained in step (c). The method can help to liberate orthopedics doctors from manual measurement of idiopathic scoliosis image processing. An idiopathic scoliosis image can be processed accurately and quickly by means of data processing, and the result can be output and displayed. The work efficiency and quality of surgeons can be greatly improved.
Owner:李书纲

Idiopathic scoliosis shape righting support pressure monitoring device

The invention provides an idiopathic scoliosis shape righting support pressure monitoring device used for monitoring the pressure applied to the spine of a patient by a shape righting support. The idiopathic scoliosis shape righting support pressure monitoring device is characterized by comprising at least five pressure sensors, a comparative judgment part, a timing part, a control part and a display part, wherein the at least five pressure sensors are fixed to predetermined positions of a shape righting support and used for sensing the pressure applied to the spine by the shape righting support, the comparative judgment part is connected with all the at least five pressure sensors and used for comparing the sensed pressure with a predetermined pressure and judging whether the pressure is smaller than the predetermined pressure, the timing part carries out accumulative timing to obtain effective pressure duration when the pressure is larger than or equal to the predetermined pressure, the control part controls the timing part to stop timing when the comparative judgment part judges that the pressure is smaller than the predetermined pressure, and the display part is used for displaying the effective pressure duration.
Owner:易红蕾

Scoliosis early-stage self-inspection and rehabilitation cloud platform

The invention provides an idiopathic scoliosis self-checking rehabilitation cloud platform. The cloud platform is characterized in that the platform comprises a preliminary checking unit, a re-checking unit and a suggestion unit, wherein the preliminary inspection unit is used for judging whether scoliosis possibility exists or not according to a preliminary inspection result and an Adams anteflexion test result; for cases with scoliosis possibility, the rechecking unit analyzes the X-ray film and further evaluates the scoliosis condition; and the suggestion unit is used for pushing suggestions of different rehabilitation schemes according to an evaluation result of the re-checking unit. The platform can effectively help consumers to carry out daily self-inspection at home.
Owner:XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE

Applications of IncRNA in preparation of products which are used for diagnosis or prediction of adolescent idiopathic scoliosis

The invention discloses novel molecular markers ENST00000414894.1 and / or TRHDE-AS1 which are related to adolescent idiopathic scoliosis. It is confirmed that expression down-regulate of ENST00000414894.1 and TRHDE-AS1IncRNA in patients with adolescent idiopathic scoliosis is induced, so that applications in preparation of products which are used for diagnosis or prediction of adolescent idiopathicscoliosis are realized. The invention also discloses applications of the molecular markers in preparation of kits which are used for diagnosis or prediction of adolescent idiopathic scoliosis. The molecular markers can be used for rapid and effective diagnosis of early stage adolescent idiopathic scoliosis. Significant importance on early stage treatment and chemical cost reduction of adolescentidiopathic scoliosis is achieved, and treatment targets and important basis are provided for clinical applications such as gene treatment and medicine treatment.
Owner:PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI

Methods for the classification and diagnosis of scoliosis through the use of gi protein receptor

Methods for diagnosing a predisposition to developing a scoliosis (e.g., adolescent idiopathic scoliosis (AIS)) and identifying compounds for treating scoliosis based on the modulation of Gi protein-coupled receptor activity are described. Specific embodiments of the methods involve measuring a change in impedance signals of cells expressing a receptor coupled to a Gi protein with a ligand. To identify compounds useful in treatment, the cell is contacted with a test compound and a ligand. A higher impedance in the presence relative to the absence of said test compound is indicative that the test compound is useful for treating scoliosis.
Owner:CHU SAINTE JUSTINE

Biomechanical-based methods of diagnosing scoliosis

Methods for diagnosing a scoliosis (e.g., adolescent idiopathic scoliosis (AIS)) and / or a predisposition to developing a scoliosis based on the determination of the variation of osteopontin (OPN) levels induced by mechanical forces / stimuli are described.
Owner:CHU SAINTE JUSTINE

Spinal cord and meninges stretching frame and method to prevent and treat the root cause of scoliosis

The progress of what has previously been considered idiopathic scoliosis it is arrested and corrected by exercises that gradually stretch the spinal cord to catch and keep up with bone growth. An inventive frame enables such exercises by precluding the movement of the spinal column that is a result of the shorter spinal cord.
Owner:SCOLIWRX INC

Methods of screening for compounds for use as modulators of left-right asymmetry in scoliotic subjects and for monitoring efficacy of an orthopaedic device

A method of screening for a compound for treating or preventing adolescent idiopathic scoliosis (AIS), said method comprising: (a) contacting a test compound with a paraspinal skin fibroblast or a paraspinal muscle cell sample from the right and / or left side of the spine of a subject; and (b) determining at least one of Nodal, Notch1, Pitx2, Lefty1 and Lefty2's expression and / or activity in the cell sample; wherein the test compound is selected as potentially useful in treating or preventing AIS if at least one of Nodal, Notch1, Pitx2, Lefty1 and Lefty2's expression and / or activity in the cell sample is different in the presence of the test compound as compared to in the absence thereof.
Owner:CHU SAINTE JUSTINE

Biofeedback System with Body Mapping Clothing for Patients with Adolescent Idiopathic Scoliosis

A biofeedback system for monitoring patient-related signals of a patient having adolescent idiopathic scoliosis (AIS) is disclosed. The present invention provides a personalized biofeedback to the patient based on the patient-related signals for restoring balance in muscle activities and reducing displacement of both sides of the patient's spine as a treatment for AIS. The biofeedback system comprises clothing integrated with posture monitoring sensors, and one or more computational systems comprising a sensor-based sEMG posture training subsystem for providing posture training and a posture monitoring subsystem for providing progressive training through daily activities. The sensor-based sEMG posture training subsystem comprises a posture training device coupled to a plurality of sEMG sensors, a feedback device and a calibration system. The posture monitoring subsystem monitors the posture of the patient and determines the properness of the posture by comparing the real-time data with the calibrated signals from the sEMG posture training subsystem.
Owner:THE HONG KONG POLYTECHNIC UNIV

Kit for predicting and screening teenager idiopathic scoliosis and application

The invention provides a kit for predicting and screening teenager idiopathic scoliosis. The kit comprises a reagent for detecting TTN gene mutation and / or expression level. By detecting the mutation condition of the TTN gene, the AIS disease suffering condition of people is predicted and screened, so that related prevention is carried out in advance, the damage of diseases to human health is remarkably reduced, meanwhile, prognosis evaluation on diseased patients is facilitated, and a reasonable and effective guiding effect is provided for treatment and rehabilitation; due to the fact that the AIS disease has obvious family genetic correlation, the TTN gene detection result can be used for providing prenatal guidance and genetic inquiry for subjects and families of the subjects, and birth of related child patients is reduced; in addition, a new drug treatment target can be provided for AIS attack of human beings, so that a new direction is provided for subsequent drug research and development, clinical treatment and the like.
Owner:JINAN UNIVERSITY

New marker for the classification, diagnosis and treatment of scoliosis

A method of classifying a subject having idiopathic scoliosis (IS) or at risk of developing IS comprising: determining the cellular response to Gi stimulation in a cell sample from the subject in the presence of OPN; determining the cellular response to Gi stimulation in a cell sample from the subject in the absence of OPN; and comparing the cellular response obtained in the presence of OPN with the cellular response obtained in the absence of OPN, whereby the comparing step enables the classification of the subject into one IS functional group. Also provided is the use of the foregoing method to classify borderline subjects and kits for applying the methods.
Owner:CHU SAINTE JUSTINE

lncRNA marker lncAIS of adolescent idiopathic scoliosis (AIS) and application of lncAIS in preparation of AIS detection, prognosis, prevention or treatment products

The invention discloses an lncRNA marker lncAIS of adolescent idiopathic scoliosis (AIS) and application of the lncAIS in preparation of AIS detection, prognosis, prevention or treatment products. Theinvention provides a kit for AIS detection and prognosis. The invention further provides a pharmaceutical composition for preventing and / or treating the AIS. The pharmaceutical composition comprisesthe lncAIS or an agonist or an analogue of the lncAIS, wherein the agonist or the analogue of the lncAIS is used as an active ingredient. The lncAIS can be used for early detection of AIS risk or disease status, and can be used for clinical application such as gene therapy and drug therapy.
Owner:PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI

Biofeedback system with body mapping clothing for patients with adolescent idiopathic scoliosis

A biofeedback system for monitoring patient-related signals of a patient having adolescent idiopathic scoliosis (AIS) is disclosed. The present invention provides a personalized biofeedback to the patient based on the patient-related signals for restoring balance in muscle activities and reducing displacement of both sides of the patient's spine as a treatment for AIS. The biofeedback system comprises clothing integrated with posture monitoring sensors, and one or more computational systems comprising a sensor-based sEMG posture training subsystem for providing posture training and a posture monitoring subsystem for providing progressive training through daily activities. The sensor-based sEMG posture training subsystem comprises a posture training device coupled to a plurality of sEMG sensors, a feedback device and a calibration system. The posture monitoring subsystem monitors the posture of the patient and determines the properness of the posture by comparing the real-time data with the calibrated signals from the sEMG posture training subsystem.
Owner:THE HONG KONG POLYTECHNIC UNIV

Methods of screening for compounds for use as modulators of left-right asymmetry in scoliotic subjects and for monitoring efficacy of an orthopaedic device

A method of screening for a compound for treating or preventing adolescent idiopathic scoliosis (AIS), said method comprising: (a) contacting a test compound with a paraspinal skin fibroblast or a paraspinal muscle cell sample from the right and / or left side of the spine of a subject; and (b) determining at least one of Nodal, Notch1, Pitx2, Lefty1 and Lefty2's expression and / or activity in the cell sample; wherein the test compound is selected as potentially useful in treating or preventing AIS if at least one of Nodal, Notch1, Pitx2, Lefty1 and Lefty2's expression and / or activity in the cell sample is different in the presence of the test compound as compared to in the absence thereof.
Owner:CHU SAINTE JUSTINE

Gi protein phosphorylation as marker for scoliosis and scoliosis progression, methods of increasing gipcr signaling in scoliotic subjects

Methods of stratifying a subject having or at risk for developing adolescent idiopathic scoliosis (AIS) into diagnostically or clinically useful subclasses are provided. The stratification is based on the subject's Giα protein serine phosphorylation profile and / or the degree of imbalance in G-protein coupled receptor responses to Giα and Gsα protein stimulation. In some embodiments, the methods involve detecting or determining the level of serine phosphorylated Giα1 and / or Giα3 proteins in the cell sample, and / or determining a ratio between the response to Giα protein stimulation and the response to Gsα protein stimulation from a biological sample from the subject. Methods for predicting the risk of an AIS subject for developing a severe scoliosis, for predicting the subject's responsiveness to bracing treatment, and for identifying therapeutically useful compounds are also provided, as well as kits therefor.
Owner:CHU SAINTE JUSTINE

System for treating idiopathic scoliosis

The present invention relates to a system for treating idiopathic scoliosis characterized in that it comprises a programmable subcutaneous or submuscular device (1) connected by means of wiring (5) to a plurality of sensors (2) which are configured to record electromyographic signals and a plurality of stimulators (3) which are configured to stimulate that part of the deep paraspinal muscles that is affected by the pathology, and wherein said device (1) comprises means for wireless data transmission, such that it may be programmed by means of an external console (4), and wherein muscle stimulation is controlled by control logic that comprises a feedback loop algorithm for adjustment of the stimulation based on the results obtained from the sensors (2) for recording the electromyographic signals and according to a musculoskeletal model, for the purpose of creating a suitable stimulus within a set time range.
Owner:TEQUIR

Whole-set primer for detecting polymorphism of rs11190870 in human genome and application of whole-set primer

The invention discloses a whole-set primer for detecting polymorphism of rs11190870 in a human genome and application of the whole-set primer. The whole-set primer for detecting the polymorphism of rs11190870 in the human genome consists of four primers which are respectively named as AIS_Fin, AIS_Rin2, AIS_F and AIS_R, wherein AIS_Fin is single stranded DNA of SEQ ID No.1; AIS_Rin2 is single stranded DNA of SEQ ID No.2; AIS_F is single stranded DNA of SEQ ID No.3; and AIS_R is single stranded DNA of SEQ ID No.4. Compared with Sanger detection, the whole-set primer is capable of shorting the detection period and lowering the detection cost and can be applied to screening and prevention of AIS high risk groups and idiopathic scoliosis of teenagers.
Owner:北京东方亚美基因科技研究院有限公司

Preparation method of zebra fish model for teenager idiopathic scoliosis

The invention discloses a preparation method of a zebra fish model for teenager idiopathic scoliosis. The preparation method comprises the following steps: S1, synthesizing RNP; s2, injecting RNP into a wild zebra fish embryo within 1 hour of birth to obtain an F0 embryo; s3, carrying out PCR detection on the mutation condition of the target site; s4, screening zebrafish genetic lines with stable gene knockout; s5, selecting tail-rolling malformed juvenile fishes, feeding the juvenile fishes until the juvenile fishes are adult, and regularly observing phenotypes; s6, extracting DNA from the adult zebra fish, and detecting to confirm that gene editing succeeds; and S7, confirming successful establishment of the model according to a DNA sequencing result and zebra fish lateral convex phenotype, belonging to the technical field of animal models, and starting from a positive result of clinical genetics screening, enabling the model to have the representativeness of the disease; a gene editing method is adopted, mutation is edited into a zebra fish genome, a Cas9 gene editing technology is used for experiment, the gene editing efficiency is ensured, and the positive rate of the constructed lateral convex model is high.
Owner:XIANGYA HOSPITAL CENT SOUTH UNIV

Biological agents promoting osteogenic differentiation of bone marrow mesenchymal stem cells

The invention discloses a biological agent for promoting osteogenic differentiation of bone marrow mesenchymal stem cells (BM-MSC), and a pharmaceutical composition for prevention and / or treatment ofadolescent idiopathic scoliosis (AIS). The inventor finds that lncAIS is key lncRNA involved in progress of AIS, wherein the lncAIS interacts with NF90 to promote HOXD8mRNA stability, thus transcription of RUNX2 in the BM-MSC is enhanced, and thus osteogenic differentiation of the normal BM-MSC is caused. By contrast, the NF90 cannot be collected due to down-regulating of the lncAIS in the BM-MSCof an AIS patient , thus the HOXD8mRNA stability is eliminated, and in this way, transcription of the RUNX2 for osteogenic differentiation is hindered. Thus, the BM-MSC of overexpression lncAIS, HOXD8or the RUNX2 can be used for preparing the biological agent for promoting osteogenic differentiation of the BM-MSC and the pharmaceutical composition for prevention and / or treatment of the AIS, and thus the new means is provided for prevention and / or treatment of the AIS.
Owner:PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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