The invention discloses a DLP projection display drive system for multiple laser sources. The DLP projection display drive system for multiple laser sources is characterized by comprising a signal processing and master controller, wherein the signal processing and master controller is connected with a video decoding circuit, a DMD drive module, a fluorescent wheel drive module, a color wheel drivemodule, a light temperature sensor module, a laser source drive interface, a power management module, an android intelligent operating system module, and an audio processing and power amplification module, an RGB three primary colors laser source driver is connected with an RGB three primary colors laser module emitting three colors of laser, a PMD 1000 chip is connected with a laser source driver, a fluorescent wheel and a color wheel separately through signals, the laser module emits laser, and the fluorescent wheel is provided with fluorescent powder that can be stimulated to generate fluorescent light of a corresponding color. According to the type of the selected laser source, no adjustment is performed on a hardware driver board, the DLP projection display drive that is suitable formultiple laser sources and is used on hardware universally can be realized only by inserting in a corresponding drive interface.