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Composition used for preparing medicines used for treating Alzheimer's Disease

A composition and drug technology, which is applied in the directions of drug combination, non-active ingredients medical preparations, medical preparations containing active ingredients, etc. Achieve the effect of improving cognition/restlessness and anxiety, improving anxiety and restlessness, reliable biosafety

Inactive Publication Date: 2018-11-02
BEIJING CAREFREEING BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Plants are the main source of traditional Chinese medicine, but there are many problems in traditional Chinese medicine, such as many useless components, containing some useless components that are harmful to the human body, and it is difficult for compatible components to produce a high synergistic effect

Method used

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  • Composition used for preparing medicines used for treating Alzheimer's Disease
  • Composition used for preparing medicines used for treating Alzheimer's Disease
  • Composition used for preparing medicines used for treating Alzheimer's Disease

Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1

[0042] Prepare various extracts: Hovenia trifoliate (purchased from Foshan Xinhang Biotechnology Co., Ltd., 99%, 10:1), rattan tea (Foshan Xinhang Biotechnology Co., Ltd., 90%), black plum (Prunus mume, CA7WM722, Conc.5:1. purchased from MasterHerbs Inc., USC), wild jujube seed (Ziziphus Jujuba, CA7SZ681, Conc.5:1. purchased from Master HerbsInc., USC), lemon (Citrus Limon, CA7NM544, Conc.5:1 . from Master Herbs Inc., USC) and sucrose (from True Cireus Co., USA). Add 100g of lemon extract to 10g of sucrose, add 100g of purified water, adjust the pH to 3, heat to boiling to dissolve all the sucrose, cool down to 90°C, and quickly mix the remaining extracts by weight:

[0043]

[0044] Mix it into the 90°C liquid from the previous step (210g of lemon extract plus sucrose liquid), stir quickly until it is completely dissolved in the liquid, and allow it to cool down naturally. During this process, sucrose is chelated with active ingredients into granules. The pasty mixture m...

preparation Embodiment 2

[0046] Same as the preparation example 1, prepare the extracts of Hovenia aurantii, vine tea, ebony plum, wild jujube seed, and lemon. Add 100g of lemon extract to 10g of sucrose, add 50g of purified water, adjust the pH to 3, heat to boiling to dissolve all the sucrose, cool down to 90°C, and quickly mix the remaining extracts by weight:

[0047]

[0048] Mix it into the 90°C liquid from the previous step (160g lemon extract plus sucrose liquid), stir quickly until it is completely dissolved in the liquid, and let it cool down naturally. During this process, sucrose is chelated with active ingredients into granules. In this way, the pasty mixture made is further processed into tablets, capsules, granules or liquid drinks according to the conventional technology of pharmacy.

preparation Embodiment 3

[0050] Same as the preparation example 1, prepare the extracts of Hovenia aurantii, vine tea, ebony plum, wild jujube seed, and lemon. Add 100g of lemon extract to 10g of sucrose, add 80g of purified water, adjust the pH to 3, heat to boiling to dissolve all the sucrose, cool down to 80°C, and quickly mix the remaining extracts according to the number of parts:

[0051]

[0052] Mix it into the 80°C liquid (190g lemon extract plus sucrose liquid), stir quickly until it is completely dissolved in the liquid, and let it cool down naturally. During this process, sucrose is chelated with active ingredients into granules. In this way, the pasty mixture made is further processed into tablets, capsules, granules or liquid drinks according to the conventional technology of pharmacy.

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Abstract

The invention discloses a pharmaceutical composition. The pharmaceutical composition comprises semen hoveniae extract product, rattan tea extract product, plum extract product, jujube kernel extract,lemon, and cane sugar. The invention also discloses applications of the pharmaceutical composition in preparation of medicine used for treating Alzheimer's Disease, and a preparation method of the pharmaceutical composition. The pharmaceutical composition is capable of increasing the level of mice Gephyrin protein, reducing mice anxiety level, and improving the cognition and distinguish disordersof Alzheimer's Disease patients, and is promising in application prospect in the field of Alzheimer's Disease treatment.

Description

technical field [0001] The invention discloses a composition, more specifically, the invention discloses a pharmaceutical composition. Background technique [0002] Alzheimer's disease (AD), commonly known as senile dementia, is a chronic progressive neurodegenerative disease that plagues 35.6 million people worldwide. Alzheimer's disease can be manifested as memory loss, aphasia, incontinence, inability to take care of oneself, etc. It is the most common dementia, accounting for 50% to 75% of the total dementia, and the incidence rate increases with age. According to the World Health Organization (WHO) 2013 report, more than 25%-50% of the 85-year-old people in the world suffer from Alzheimer's dementia, and the economic cost of the social burden that these Alzheimer's dementias currently poses in the world More than 204 billion US dollars per year. In high-income countries, informal care (45%) and formal social care (40%) account for the majority of costs, while direct m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/87A61P25/28
CPCA61K36/72A61K36/725A61K36/736A61K36/752A61K36/87A61K47/26A61P25/28A61K2300/00
Inventor 梁京
Owner BEIJING CAREFREEING BIOTECHNOLOGY CO LTD
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