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Preparation method of nine flavor swertia bimaculata tablet and application of nine flavor swertia bimaculata tablet in preparation of drugs for inhibition of cell proliferation of teratoma cell P19

A technology of Jiuwei Swertia Swertia Tablets and Swertia Swertiae, which is applied in the fields of antineoplastic drugs, drug combinations, drug delivery, etc., and can solve the problems of rough process, affecting clinical application, and many impurities

Inactive Publication Date: 2015-03-11
SHANDONG ZHONGDA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no Jiuwei Swertia Capsules that use CO in the extraction and preparation 2 There are reports of supercritical extraction, microwave technology and macroporous resin adsorption technology for extraction, while the method of directly powdering traditional Chinese medicine is rough, backward, and has many impurities, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects the clinical application of this product. application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Take 53.6g of Swertia japonica, 17.9g of golden waist grass, 35.7g of Bangga, 35.7g of woody fragrance, 35.7g of rabbit ear grass, 42.9g of bitter fennel, 35.7g of horned fennel, 28.6g of barberry bark, and 14.2g of melon seeds. g: Take woody and horned fennel, grind them into fine powder, add to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer to the total extraction solvent is 5%, the extraction pressure is 25MPa, the temperature is 40°C, and the CO 2 The flow rate is 2ml / g crude drug·min, the extraction time is 150min, and the supercritical extract is obtained, which is used for later use; after the extraction, the residue of woody fragrance, horned fennel, and other seven-flavored medicinal materials are crushed, and 2L of 60% ethanol is added, and put into a microwave extraction device for microwave extraction. Extraction, extraction power 700W, extraction 2 times, 8 minutes each time, combined extract...

Embodiment 2

[0033] Take 53.6g of Swertia japonica, 17.9g of golden waist grass, 35.7g of Bangga, 35.7g of woody fragrance, 35.7g of rabbit ear grass, 42.9g of bitter fennel, 35.7g of horned fennel, 28.6g of barberry bark, and 14.2g of melon seeds. g: Take woody and horned fennel, grind them into fine powder, add to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 4%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3ml / g crude drug·min, the extraction time is 130min, and the supercritical extract is obtained for later use; after the extraction, the residues of woody fragrance, horned fennel and other seven-flavored medicinal materials are crushed, and 2L of 60% ethanol is added, and put into a microwave extraction device for microwave extraction. Extraction, extraction power 600W, extraction 2 times, 8 minutes each time, combined extracts, concentrated...

Embodiment 3

[0036] Take 53.6g of Swertia japonica, 17.9g of golden waist grass, 35.7g of Bangga, 35.7g of woody fragrance, 35.7g of rabbit ear grass, 42.9g of bitter fennel, 35.7g of horned fennel, 28.6g of barberry bark, and 14.2g of watermelon seeds. g: Take woody and horned fennel, grind them into fine powder, add to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 20MPa, the temperature is 30°C, and CO 2The flow rate is 1ml / g crude drug·min, the extraction time is 170min, and the supercritical extract is obtained, and it is used for later use; after extraction, the residue of woody fragrance, horned fennel, and other seven-flavored medicinal materials are crushed, added 2L of 60% ethanol, and put into a microwave extraction device for microwave extraction. Extraction, extraction power 800W, extraction 2 times, 10 minutes each time, combined extracts, concentr...

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Abstract

The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a preparation method and application of a nine flavor swertia bimaculata tablet. The nine flavor swertia bimaculata tablet is prepared from 53.6g of swertia bimaculata, 17.9g of chrysosplenium, 35.7g of herba aconiti, 35.7g of radix aucklandiae, 35.7g of lagotis brevituba maxim, 42.9g of indian lettuce, 35.7g of hypecoum erectum, 28.6g of cortex berberidis and 14.2g of herpetospermum seed as raw material medicines by supercritical fluid extraction, microwave extraction and macroporous resin adsorption, and the content of berberine hydrochloride is greatly improved. The invention also provides application of the nine flavor swertia bimaculata tablet in preparation of drugs for inhibition of cell proliferation of teratoma cell P19 in mice.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a preparation method of Jiuwei Swertia Swertia Tablets and its application in the preparation of drugs for inhibiting the proliferation of mouse teratoma cell P19 cells. Background technique [0002] The standard number of Jiuwei Swertia Capsules is WS-11182 (ZD-1182)-2002, which is recorded in the National Compilation of Chinese Patent Medicine Standards, Internal Medicine Hepatobiliary Subvolume. Swertia 53.6g, Golden Waist Grass 17.9g, Bangga 35.7g, Woody Fragrance 35.7g, Rabbit Ear Grass 35.7g, Bitter Anise 42.9g, Anise 35.7g, Berberis Bark 28.6g, Melon Seeds 14.2 g is made as a raw material medicine, which has the effects of clearing away heat, reducing inflammation and relieving pain. For cholecystitis, acute icteric hepatitis. [0003] In the prior art, there is no Jiuwei Swertia Capsules that use CO in the extraction and preparation 2 ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61K9/20A61P35/00
CPCA61K36/51A61K9/0053A61K9/2059A61K36/185A61K36/28A61K36/285A61K36/29A61K36/42A61K36/66A61K36/714A61K36/898A61K2236/15A61K2236/33A61K2236/333A61K2236/37A61K2236/51A61K2300/00
Inventor 权栋栋朱立平陈云李加美王丽丽
Owner SHANDONG ZHONGDA PHARMA
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