Anti-pulmonary fibrosis application of DDR2 small-molecule inhibitor

A technology of small molecule inhibitors and pulmonary fibrosis, which is applied in the field of application of DDR2 small molecule inhibitors in the preparation of anti-pulmonary fibrosis drugs, can solve the problem of no breakthrough in early prevention and treatment, unclear exact mechanism of pulmonary fibrosis, There are no reports on the application of small molecule inhibitors of DDR2 to achieve the effect of alleviating pulmonary fibrosis and improving the condition of pulmonary fibrosis
CN104490889AInactive Publication Date: 2015-04-08FOURTH MILITARY MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
FOURTH MILITARY MEDICAL UNIVERSITY
Publication Date
2015-04-08
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses an anti-pulmonary fibrosis application of a DDR2 small-molecule inhibitor, belonging to the technical field of biological medicines. In a DDR2 gene deletion mouse model, the pulmonary fibrosis condition can be remarkably improved through D856 in case of simultaneously giving bleomycin and the DDR2 small-molecule inhibitor D856; even in a homozygous mouse for restoring expressing DDR2, the inhibitor also can achieve the effect of relieving pulmonary fibrosis. On cell lever, the inhibitor D856 is added to lower the content of alpha-SMA. In an experiment of giving an inhibitor within different days, the pulmonary fibrosis also can be remarkably relieved even the inhibitor D856 is given from the 14th day, and the same result is obtained by verifying the small interference RNA of DDR2. The experimental results sufficiently support of the application of the DDR2 small-molecule inhibitor D856 to preparing an anti-pulmonary fibrosis drug and / or a health product.
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Description

technical field

[0001] The invention belongs to the technical field of biomedicine, relates to the field of prevention and treatment of pulmonary fibrosis, and specifically relates to the application of DDR2 small molecule inhibitors in the preparation of anti-pulmonary fibrosis drugs. Background technique

[0002] Various types of pulmonary fibrosis (pulmonary fibrosis, PF) are characterized by fibroblast (fibroblast, Fb) proliferation and a large number of extracellular matrix (ECM) accumulation. Various factors can cause pulmonary fibrosis, such as occupational dust (SiO 2 etc.), radiation injury and certain drugs (bleomycin), etc., in addition to a type of pulmonary fibrosis of unknown etiology - idiopathic pulmonary fibrosis (IPF). Although the causes are different, the development and outcome of fibrosis are basically similar, that is, it starts with the infiltration of inflammatory cells in the lower respiratory tract, and gradually causes damage to alveolar epitheli...

Claims

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