Pharmacological action research method of rana japonica oil freeze-dried powder for improving pulmonary fibrosis

Abstract

The invention discloses a pharmacological action research method of rana japonica oil freeze-dried powder for improving pulmonary fibrosis. The method comprises the following steps: a pulmonary fibrosis model is established, drug administration is conducted in a grouped mode, the influences of the rana japonica oil freeze-dried powder on the concentrations of tumor necrosis factors-alpha, interleukin-6, and interleukin-17 in serum of of pulmonary fibrosis rats, the influence of the rana japonica oil freeze-dried powder on the contents of hydroxyproline, malondialdehyde, superoxide dismutase, glutathione peroxidase and catalase in pulmonary tissue of the pulmonary fibrosis rats, and the influences of the rana japonica oil freeze-dried powder on pathological changes of the pulmonary tissue of the pulmonary fibrosis rats and the content of the hydroxyproline are researched, and overall evaluation is carried out according to the research. According to the research method, the rana japonicaoil freeze-dried powder can be researched in the multiple aspects of the influences of pulmonary fibrosis, a systematic evaluation method is formed, and the research method has great significance todevelopment of a rana japonica oil freeze-drying process and popularization of freeze-dried products.

Description

technical field [0001] The invention relates to the technical field of health food, in particular to a method for researching the pharmacological effect of Rana oil freeze-dried powder on improving pulmonary fibrosis. Background technique [0002] Rana, also known as toad, is a famous economic frog species in my country that integrates medicinal, nourishing and beauty. Rana oil is the fallopian tube of the female Rana frog, which contains 18 kinds of amino acids, 13 kinds of inorganic elements, 9 kinds of vitamins and a variety of compound polypeptides and other biologically active factors, especially rich in three sex hormones, namely estradiol, Testosterone, progesterone. Among them, estradiol and testosterone are the hormones with the strongest physiological effects among estrogen and androgen respectively, and have significant functions of nourishing yin and strengthening kidney, stimulating immune function and regulating mechanism. It has a good effect on the improvem...

AI Technical Summary

Problems solved by technology

However, long-term high-temperature cooking makes the nutrient loss of wood frog oil serious, and its active substances with efficacy are destroyed, such as unsaturated fatty acids, vitamin E, vitamin C and estradiol, etc., seriously affecting its efficacy

In addition, high-temperature cooking can only eliminate most of the fishy smell, and the finished wood frog oil still has a slight fishy smell. At the same time, the wood frog oil after high-temperature cooking is not soft enough, which affects its taste

Therefore, more and more technologies are pointing to the research on the freeze-drying of Rana oil. The freeze-drying process makes the Rana oil convenient and quick to use, but whether the freeze-dried Rana oil will have functional impact, the existing The technology is still less researched, and there is a lack of systematic research methods to study the pharmacological effects of Rana oil freeze-dried powder on pulmonary fibrosis repair, which hinders the development process and wide promotion of Rana oil products

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