A composition for promoting regeneration of dental pulp and dentin

A composition and dentin technology, applied in the field of dental treatment, can solve problems such as unclear regeneration of dental pulp

Active Publication Date: 2018-05-11
新科沃再生医学(苏州)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is currently unclear whether amelogenin can obtain true regenerated dental pulp containing blood vessels and nerves.

Method used

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  • A composition for promoting regeneration of dental pulp and dentin
  • A composition for promoting regeneration of dental pulp and dentin
  • A composition for promoting regeneration of dental pulp and dentin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037]A composition for promoting dental pulp and dentin regeneration, including platelet-derived growth factor PDGF and scaffold material, the concentration of platelet-derived growth factor PDGF is 20ng / mL, platelet-derived growth factor PDGF is PDGF-BB, and PDGF-BB is combined The final concentration in the root canal was 10ng / mL, the concentration of PDGF near the coronal end of the root canal was 100ng / ml, and the concentration near the apical end of the root canal was 80ng / ml, and the concentration of PDGF near the root canal was 80ng / ml. The release amount of the apical end of the canal reaches 75% after two days, and reaches 80% after seven days, and the release amount of platelet-derived growth factor PDGF near the root canal crown reaches 60% after two days, and reaches 80% after seven days; the scaffold material is Fibrinogen component and thrombin component, the final concentration of the fibrinogen component is 8 mg / ml, the final concentration of the thrombin compo...

Embodiment 2

[0040] A composition for promoting regeneration of dental pulp and dentin, including platelet-derived growth factor PDGF and scaffold material, the concentration of platelet-derived growth factor PDGF is 500ng / mL, and platelet-derived growth factor PDGF is a mixture of PDGF-BB and PDGF-AB The final concentration of the PDGF-BB in the platelet-derived growth factor PDGF in the composition is 140ng / mL, the concentration of the platelet-derived growth factor PDGF is 500mg / ml near the coronal end of the root canal, and the concentration near the apical end of the root canal 220ng / ml, the release of platelet-derived growth factor PDGF near the apical end of the root canal reached 80% after two days, and reached 85% after seven days, and the release of platelet-derived growth factor PDGF near the root canal crown reached 80% after two days up to 62%, and 82% after seven days; the scaffold material is fibrin gel component, fibrinogen component and thrombin component, wherein the final...

Embodiment 3

[0043] A composition for promoting dental pulp and dentin regeneration, including platelet-derived growth factor PDGF and scaffold material, the concentration of platelet-derived growth factor PDGF is 800ng / mL, and the platelet-derived growth factor PDGF is PDGF-BB, PDGF-AB and PDGF - A mixture of AA, PDGF-BB in the composition of platelet-derived growth factor PDGF at a final concentration of 220 ng / mL, platelet-derived growth factor PDGF at a concentration of 750 mg / ml near the coronal end of the root canal and near the root of the root canal The concentration at the apical end was 240ng / ml, the release of platelet-derived growth factor PDGF near the apical end of the root canal reached 85% after two days, and reached 90% after seven days, and the release of platelet-derived growth factor PDGF near the root canal crown The amount reaches 65% after two days, and reaches 85% after seven days; the scaffold material is fibrin gel component, fibrinogen component, hyaluronic acid c...

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Abstract

The invention discloses composition for promoting regeneration of dental pulp and dentin. The composition comprises a PDGF (platelet-derived growth factor) and a scaffold, wherein the PDGF adopts one or more of PDGF-BB, PDGF-AB and PDGF-AA; the scaffold adopts one or more of alginate, Arabic gum, guar gum, xanthan gum, gelatin, chitin, chitosan, chitosan acetate, chitosan lactate, chondroitin sulfate, N,O-carboxymethyl chitosan, glucan, fibrin glue, fibrinogen, natural blood clots, glycerol, hyaluronic acid, gourmet powder, glucosamine, proteoglycan, starch, lactic acid, poloxamer, sodium glycero-phosphate, collagen, glycogen, a keratin filament, a synthetic surgical sealant and a synthetic surgical adhesive. The composition can be conveniently injected into a dental pulp cavity required to be treated, repairing cells enter the dental pulp cavity and play the repair role under combined action of the PDGF and the scaffold, so that the diseased dental pulp and dentin are regenerated and repaired.

Description

technical field [0001] The invention relates to the field of dental treatment, in particular to a composition for promoting regeneration of dental pulp and dentin. Background technique [0002] Most of the biological activity of the tooth mainly depends on the pulp. Currently, covering or replacing it with an inert synthetic material, i.e. root canal therapy, is the main way to treat pulp diseases. The more common filling material is Eucommia gum, which is an isoprene thermoplastic polymer. For treatment, after the dead pulp is removed, molten hot gutta-percha is injected into the root canal. Although root canal therapy has been widely used in dental treatment in recent years, there are still the following disadvantages: the teeth after root canal therapy are more brittle and easy to break; teeth after root canal therapy frequently discolor, and the cost of later dental cosmetic surgery is high ; There is no root canal treatment for diseased teeth in infants. Moreover, th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/18A61L27/54A61L27/20A61L27/22A61L27/36A61L27/00A61L27/18A61P1/02
Inventor 毛剑刘永兴周建
Owner 新科沃再生医学(苏州)有限公司
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