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Kit for evaluating male urine sodium value within 24 hours

A 24-hour, kit-based technology, applied in the field of medicine, can solve problems such as cumbersome procedures, inconvenience for patients, and inconvenient intake of urinary sodium

Active Publication Date: 2015-06-10
PEOPLES HOSPITAL PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

24-hour urine sodium measurement is the most reliable and accurate method at present, but the 24-hour urine collection time is long and the process is cumbersome, which brings a lot of inconvenience to patients
my country is a country with high blood pressure, and many hypertensive patients seek medical treatment at the grassroots level. It is extremely inconvenient to use 24-hour urine sodium measurement to evaluate urine sodium intake

Method used

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  • Kit for evaluating male urine sodium value within 24 hours
  • Kit for evaluating male urine sodium value within 24 hours
  • Kit for evaluating male urine sodium value within 24 hours

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1, establishment of the inventive method

[0035] The data come from hypertensive patients hospitalized in the hypertension ward of Peking University People's Hospital from August 2011 to November 2012. Inclusion criteria: ①The diagnosis of hypertension was clear. The diagnostic criteria of hypertension were based on the 2010 Chinese guidelines for the prevention and treatment of hypertension. Hypertension was defined as systolic blood pressure ≥ 140mmHg (1mmHg = 0.133kPa) and (or) diastolic blood pressure ≥ 90mmHg when blood pressure was measured 3 times on different days without using antihypertensive drugs. The patient had a history of hypertension in the past and was currently using antihypertensive drugs. His blood pressure was <140 / 90mHg, and he was also diagnosed as hypertension. ② Stable regular diet in the past 1 month. ③ Fill in the informed consent. Exclusion criteria: ①Hypertension accompanied by severe multi-system diseases (such as rheumatic...

Embodiment 2

[0046] Embodiment 2, verification of the inventive method

[0047] There were 96 male patients in the verification group, and the predicted value of urine sodium (e-24HUNa) was calculated by Kawasaki method, Tanaka method and SUN1 method respectively, and the accuracy was compared with the predicted value and the measured value (r-24HUNa) , the results are shown in Table 1:

[0048] Table 1 Accuracy comparison of three methods

[0049]

[0050] *P is the chi-square test value compared with the SUN1 method

[0051] It can be seen from Table 1 that compared with the K method, the 30% accuracy of the SUN1 method for estimating e-24HUNa is not statistically significant (P>0.05), but the 50% accuracy is significantly improved (P0.05), suggesting that the accuracy of SUN1 method for estimating e-24HUNa was equivalent to T method.

[0052] figure 1 Bland-Altman plot of predicted urinary sodium versus measured urinary sodium for K-method SMU.

[0053] figure 2 Bland-Altman pl...

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Abstract

The invention provides a kit for evaluating a male urine sodium value within 24 hours. The kit provided by the invention comprises a product for detecting a point urine sodium value, a product for detecting a point urine creatinine value and a carrier with the following formula: e-24HUNa=0.225*PRC*(SUNa / SUCr)<0.310>, wherein PRCr represents a predicted 24h urine creatinine value and is equal to e<6.916-0.007*age-0.002*height+0.013*weight)>; e-24HUNa represents a predicted 24h urine sodium value; SUNa represents the point urine sodium value; SUCr represents the point urine creatinine value; SUNa / SUCr represents the ratio of the point urine sodium value to the point urine creatinine value. Compared with that determined by a conventional Kawasaki method and Tanaka method, the male urine sodium value within 24 hours predicted by using the kit is equivalent in accuracy, and the kit plays an important role in helping to judge whether the salt intake of a hypertensive exceeds the standard or not and guiding the living style and drug therapy of the hypertensive.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a kit for evaluating male 24-hour urine sodium value. Background technique [0002] High salt is an important environmental factor for the occurrence of hypertension. Most research results have confirmed that high-salt diet is an important risk factor for high blood pressure. By reducing salt intake, the effect of lowering blood pressure is more obvious, especially for those who are sensitive to salt. High salt intake is associated with hypertensive target organ damage such as left ventricular hypertrophy, arteriosclerosis, proteinuria, and the incidence and mortality of cardiovascular and cerebrovascular events. Salt restriction has a protective effect on target organs independent of the antihypertensive effect . Therefore, salt restriction intervention can not only prevent and control hypertension and reduce the incidence of hypertension, but also reduce cardiovascular adv...

Claims

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Application Information

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IPC IPC(8): G01N33/50
CPCG01N33/50
Inventor 孙宁玲张志丽王鸿懿王鲁雁喜杨马志毅赵立超王及华陈源源韩伟中
Owner PEOPLES HOSPITAL PEKING UNIV
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