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Combined application and method for detecting GRK4 mutant, systolic pressure variation and urine sodium excretion rate

A technology of urinary sodium excretion and variant, applied in the field of diagnosis, can solve problems such as the decline of dopamine receptor function, and achieve the effect of better patient compliance, better diagnostic salt sensitivity, and better patient compliance.

Inactive Publication Date: 2015-07-15
THE THIRD AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIV OF PLA
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

Because the function of dopamine receptors is regulated by GRK4, GRK4 has variants such as A142V, A486V, and R65L in the human body. The existence of these variants increases the activity of GRK4, resulting in a decrease in the function of dopamine receptors.
Whether GRK4 can be used as a salt-sensitive identification indicator has not been reported

Method used

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  • Combined application and method for detecting GRK4 mutant, systolic pressure variation and urine sodium excretion rate
  • Combined application and method for detecting GRK4 mutant, systolic pressure variation and urine sodium excretion rate
  • Combined application and method for detecting GRK4 mutant, systolic pressure variation and urine sodium excretion rate

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Embodiment Construction

[0025] The preferred embodiments of the present invention will be described in detail below with reference to the accompanying drawings. Experimental methods not indicating specific conditions in the examples or according to the conditions suggested by the manufacturer.

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Abstract

The invention discloses a combined application and method for detecting a GRK4 mutant, systolic pressure variation and urine sodium excretion rate. The method concretely comprises the steps of firstly, measuring the systolic pressure variation and the urine sodium excretion rate delta SBP/UNa<+>; detecting whether GRK4 is a mutant; and finally, judging whether a testee is slat-sensitive or salt-nonsensitive according to the fact that whether SBP/UNa<+> and GRK4 are mutants. The method is high in sensitivity for judging salt sensitivity, good in specificity, rapid and effective; the patient compliance is good; the effect of the method is better than that of a venous brine loading method; a novel marker and method are provided for clinically judging the salt sensitivity; and the method has important clinical significance.

Description

technical field [0001] The invention belongs to the field of diagnosis, and in particular relates to the application and method of jointly preparing a reagent for diagnosing salt sensitivity with a reagent for detecting GRK4 variants and the ratio of systolic blood pressure change to urinary sodium excretion rate. Background technique [0002] Salt is one of the most important environmental factors, but individuals have different blood pressure responses to salt load or salt restriction, and individuals are divided into salt-sensitive and salt-insensitive according to their blood pressure response to high salt intake and the degree of sodium retention Two categories. The detection rate of sensitive people in the normal population ranges from 15% to 42%; the proportion of salt-sensitive individuals with high blood pressure in the future is significantly higher than that of non-salt-sensitive individuals, and their chances of coronary heart disease and stroke are also greatly ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68
Inventor 曾春雨张晔于长青唐辉李良鹏陈垦
Owner THE THIRD AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIV OF PLA
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