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Method and device for measuring 24-hour urine sodium discharge amount of children and adolescents

A 24-hour, measurement method technology, applied in the field of clinical testing, which can solve problems such as poor accuracy, underestimation of actual sodium intake, and deviation of sodium intake

Active Publication Date: 2020-12-15
BEIJING CHILDRENS HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Through the Bland-Altman analysis, it can be seen that there are more obvious systematic errors; on the other hand, it is also more important that when evaluating the accuracy, although the difference between the estimated value of the population mean level and the measured value is small, it is largely due to "Underestimation" and "overestimation" offset each other, resulting in
Estimation of 24-hour urinary sodium excretion by a single time-point urine is used to estimate sodium intake, but the accuracy is poor, and there is a large deviation in the estimated individual sodium intake, and the existing models tend to underestimate the actual sodium intake
Estimation of urinary sodium excretion in children based on the predictive model of adult single-point urine is more likely to lead to misjudgment

Method used

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  • Method and device for measuring 24-hour urine sodium discharge amount of children and adolescents
  • Method and device for measuring 24-hour urine sodium discharge amount of children and adolescents
  • Method and device for measuring 24-hour urine sodium discharge amount of children and adolescents

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Example 1 Establishment of 24-hour Urinary Sodium Excretion Measurement Method for Children and Adolescents

[0065] 1. Research object

[0066] A total of 151 children who visited Beijing Children's Hospital Affiliated to Capital Medical University were collected as research objects. The exclusion criteria for the population included:

[0067] (1) Children with renal impairment or renal insufficiency;

[0068] (2) Children treated with diuretics;

[0069] (3) Children with congenital diseases such as congenital hypospadias and congenital heart disease;

[0070] (4) Children with secondary infection after admission;

[0071] (5) Children with acute / chronic heart failure;

[0072] (6) Children suffering from diseases that affect dietary intake (such as malignant tumors, etc.).

[0073] The collected information includes the gender, age, drinking water volume of the above-mentioned groups of people on the day of urine sample collection, whether samples were missed or...

Embodiment 2

[0114] Embodiment 2 The model effect detection that the present invention constructs

[0115] 1. Comparison with the relative deviation distribution of existing models

[0116] 1) method

[0117] The difference between the model estimated value and the measured value is defined as the difference between the estimated value and the measured value of the 24-hour urinary sodium excretion, that is, the estimated value-the measured value. The formula for calculating the relative deviation of 24-hour urinary sodium excretion is as follows:

[0118] Relative deviation = (estimated value - measured value) / measured value × 100% The larger the relative deviation, the worse the consistency between the estimated value and the measured value. Generally speaking, the maximum acceptable relative deviation in practice is generally lower than 30% .

[0119] 2) Results

[0120] The result is as figure 2 As shown, the results show that the existing models based on single time-point urine...

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Abstract

The invention provides a method and a device for measuring the 24-hour urine sodium discharge amount of children and adolescents. The method comprises the following steps: collecting time-point urinetwice, and detecting the average content of urine sodium and the average content of urine creatinine contained in the time-point urine collected twice. Compared with the prior art, the determination method has the advantages that the estimation accuracy is greatly improved, the estimation error rate is lower than 30%, and the determination method plays an important role in helping to judge whetherthe salt intake of children exceeds the standard or not and guiding healthy diet.

Description

technical field [0001] The invention belongs to the field of clinical detection, and relates to a method and a device for measuring 24-hour urine sodium excretion of children and adolescents. Background technique [0002] Sodium intake plays an important role in regulating blood pressure in children. Elevated blood pressure in childhood is an important risk factor for hypertension and cardiometabolic diseases in adulthood, and its persistent effect significantly increases the risk of cardiovascular disease in adulthood. Salt tastes develop in childhood, but children's taste preferences for salt are easily changed. Parents are concerned about children's health. Gradually reducing children's sodium intake in specific foods can reduce children's preference for salty tastes, reduce the risk of cardiovascular disease in adulthood, and benefit for life. This has become one of the important tasks of primary prevention of cardiovascular disease. The premise of achieving this goal ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/48G16H10/40G16H50/30
CPCG01N33/48G16H10/40G16H50/30
Inventor 彭亚光彭晓霞张莹严若华李昆聂晓璐蔡思雨刘雅莉武泽昊
Owner BEIJING CHILDRENS HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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