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New use of vitexin xyloside

A technology of vitexin xyloside and diabetes, which is applied in the field of new application of vitexin xyloside to achieve excellent effect, lower blood sugar and blood fat, and reduce the incidence of disease

Active Publication Date: 2015-10-07
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, no literature has reported that vitexin xyloside has the effect of lowering blood sugar and blood fat

Method used

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  • New use of vitexin xyloside
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  • New use of vitexin xyloside

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1: Pharmacological study of vitexin xyloside in lowering blood sugar and blood fat

[0028] 1 Materials and methods

[0029] 1.1 Test material

[0030] 1.1.1 Experimental animals

[0031] 40 male C57BL / KsJ-db / db diabetic mice (db / db mice), 6 weeks old, weighing 30.5±2.1g, were purchased from Changzhou Cavens Experimental Animal Co., Ltd.

[0032] 1.1.2 Main instruments

[0033] OneTouch blood glucose meter, American Johnson & Johnson.

[0034] OneTouch blood glucose test strips, American Johnson & Johnson.

[0035] Hitachi 7180 automatic biochemical analyzer, Hitachi, Japan.

[0036] 1.1.3 Reagents and Reagents

[0037] Vitexin Xyloside (purity greater than 98%, Apin Chemicals Limited)

[0038] Metformin Hydrochloride Tablets (Shenzhen Zhonglian Pharmaceutical Co., Ltd.)

[0039] 1.2 Test method

[0040] Place 40 male db / db mice in an animal room with fixed temperature and humidity and feed them with common basal feed, with a temperature of 20±2°C and a...

Embodiment 2

[0052] Example 2: Pharmacological study of vitexin xyloside for lowering blood fat

[0053] 1 Materials and methods

[0054] 1.1 Test material

[0055] 1.1.1 Experimental animals

[0056] 60 clean and healthy 6-week-old Kunming mice, half male and half male, weighing 20±2g (provided by the Experimental Animal Center of Guangxi Medical University).

[0057] 1.1.2 Main instruments

[0058] OneTouch blood glucose meter, American Johnson & Johnson.

[0059] OneTouch blood glucose test strips, American Johnson & Johnson.

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PUM

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Abstract

The invention relates to a new use of vitexin xyloside, and concretely relates to an application of the vitexin xyloside in the preparation of medicines for treating metabolic diseases. The metabolic diseases are hyperlipidemia or hyperglycemia, and complications thereof. A test result shows that the vitexin xyloside has obvious diabetic mouse blood sugar and blood fat reducing effects, and is better than substances in the prior art, and the action of the vitexin xyloside has a certain dose-effect relationship.

Description

technical field [0001] The invention relates to a new application of vitexin xyloside, in particular to the application of vitexin xyloside in the preparation of medicines for treating hyperglycemia or hyperlipidemia and the complications caused by them. Background technique [0002] Vitexin xyloside or vitexin xyloside, its English name is vitexin-2″-O-xyloside, vitexin-2-O-xyloside, molecular formula C 26 h 28 o 14 , molecular weight: 564, the structural formula is as follows: [0003] [0004] Reports involving the use of related drugs and their derivatives include: [0005] CN201110128215.8 (publication number is CN102219782A) discloses a method for extracting and separating vitexin and isovitexin from natural products. , Anti-cancer and anti-tumor effects. [0006] CN201010184455.5 (publication number is CN101849918A) provides a preparation method of vitexin-2″-O-rhamnoside dripping pills, and discloses that the medicine has the effect of treating chest pain and...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P3/10A61P3/06A61P3/00A61P9/10A61P7/02A61P1/16
Inventor 潘小姣邓家刚汪泉甄汉深韦志英
Owner GUANGXI UNIV OF CHINESE MEDICINE
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