Treatment of diseases involving mucin

A mucin, disease technology, applied in the field of disease treatment involving mucin, can solve the problem of increasing the cytotoxicity of chemotherapy drugs, etc.

Active Publication Date: 2015-10-07
NEWSOUTH INNOVATIONS PTY LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has now been unexpectedly found that a composition comprising one or more compounds in bromelain and at least one mucolytic agent is effective in reducing the production of mucin and assisting in its removal from the body, having a direct effect on tumor growth Inhibitory effect, and can increase the cytotoxicity of chemotherapeutic drugs

Method used

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  • Treatment of diseases involving mucin
  • Treatment of diseases involving mucin
  • Treatment of diseases involving mucin

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0128]

[0129] A. Pseudomyxoma peritonei

[0130] Experiment 1 (Laboratory)

[0131] Table 1 shows the results in PMP tumors from 31 patients who were peritoneotomized. Table 1 shows that treatment with Br and NAC alone is ineffective. Tumor / mucin samples were taken from the abdomen and then treated with 300 μg / ml Br, 5% NAC or a mixture of both in the laboratory at 37°C for 3 hours. Measure the weight of the mucin tumors before and after treatment. In 16 patient samples there was a complete or >90% disappearance of the tumor when using the combination of Br+NAC and in each case there was no (or very little) reduction in weight with Br or NAC alone.

[0132] Table 1: Breakdown of mucins with improved enzyme preparations

[0133]

[0134]

[0135]

[0136]

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[0138]

[0139]

[0140] Experiment 2 (Laboratory)

[0141] figure 1 The time course of dissolution of human PMP mucin in the laboratory is shown. Again it was found that the control...

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Abstract

The present invention relates to compositions containing one or more of the compounds contained in bromelain, or salts, solvates or prodrugs thereof, and one or more mucolytic agents, or salts, solvates or prodrugs thereof, for treatment of diseases involving mucin, especially mucin secreting cancers, or diseases involving blood clots (thrombi).

Description

field of invention [0001] In general, the present invention relates to compositions for the treatment of diseases involving mucins, in particular for the treatment of mucin-secreting cancers. Furthermore, the composition of the invention relates to a composition for the treatment of diseases involving blood clots (thrombus). Background of the invention [0002] Mucins are a family of high molecular weight, highly glycosylated proteins produced by epithelial tissues including the gastrointestinal tract, lung, kidney, ovary, breast and pancreas. Under normal physiological conditions, mucins exert a protective effect on epithelial tissue. However, mucins can also be involved in disease states (eg cystic fibrosis). The inability to cough up mucus can lead to disorders including respiratory disease and pancreatic pathology. [0003] High levels of mucin expression are associated with metabolic and poor clinical outcomes in patients diagnosed with cancer. Normally, the synthes...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/80A61P25/28A61K33/243
CPCA61K36/88A61K31/198A61K38/1709A61K38/4873A61K45/06C12Y304/22032C12Y304/22033A61P1/04A61P1/16A61P1/18A61P11/00A61P11/10A61P13/08A61P15/00A61P19/02A61P25/28A61P27/16A61P31/00A61P35/00A61P43/00A61P5/14A61P7/02A61P7/04A61P9/00A61P9/10A61K33/243A61K2300/00
Inventor D·L·莫里斯罗杰·阿斯顿贾韦德·阿赫塔尔克里希那·皮莱
Owner NEWSOUTH INNOVATIONS PTY LTD
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