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Method for preparing morroniside

A technology of morroniside and cornus officinalis, which is applied in the field of raw drug preparation, can solve problems such as high production and preparation costs, poor stability of morroniside, and hindered use and promotion, and achieve low product cost, small solvent consumption, and shortened heating time Effect

Active Publication Date: 2015-10-21
BEIJING INST FOR DRUG CONTROL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the poor stability of morroniside, it is easy to decompose when encountering heat and acid and alkali, resulting in high production and preparation costs, and hindering the use and promotion of morroniside.

Method used

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  • Method for preparing morroniside

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Experimental program
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Effect test

Embodiment

[0033]1) Take 2 kg of Cornus officinalis, crush it into coarse parts (20 meshes), use 70% methanol (the volume ratio of water to alcohol is 30:70) as solvent, and extract by percolation, the specific method is: put the cornus officinalis in In a sealed container, add the solvent methanol and infiltrate for 2 hours to make the dogwood fully swell, and put it into the percolator with multi-layer gauze at the bottom evenly, and press it with a wooden stick after each installation. Cover the dogwood with gauze and press a heavy object, open the switch of the lower port of the percolator, and then slowly add 70% methanol from the upper part of the percolator, when the liquid starts to flow out from the lower port, turn off the switch and keep the upper liquid level high Leave the drug surface 5 cm away, then cover and place it for 24 hours, open the switch at the lower port, let the percolate flow out slowly, collect 6L percolate, and obtain the extract of Cornus officinalis;

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Abstract

The invention discloses a method for preparing morroniside. The method comprises the following steps: 1) carrying out permeating extraction on cornus officinalis to obtain a cornus officinalis extraction solution; 2) concentrating the cornus officinalis extraction solution obtained in the step 1) to obtain cornus officinalis extract; 3) uniformly mixing the cornus officinalis extract with a silica gel, drying and grinding the mixture, and filling the mixture in a chromatographic column, wherein the chromatographic column is filled with a hollow silica gel for chromatography; and 4) eluting the chromatographic column by using an eluant and collecting a flowing component, then removing the eluant in the flowing component, dissolving residues by methanol, and carrying out recrystallization to obtain morroniside. The purity of the product obtained by the method is greater than 70%, so that the product can be used for further purification and production of high purity morroniside and can be directly used for producing various target products. The method not only is suitable for small-scaled preparation in a lab, but also is suitable for large-scaled industrial production.

Description

technical field [0001] The invention belongs to the field of raw material medicine preparation and relates to a method for preparing morroniside. Background technique [0002] Morroniside (morroniside) is the main component of the traditional Chinese medicine Cornus officinalis, in which morroniside has neuroprotection, anticoagulant and platelet aggregation, protection of cardiomyocytes, inhibition of melanin formation, and promotion of fracture healing. It has good protective and repairing effects on ischemic brain injury. At present, morroniside is mainly used for the content determination of the traditional Chinese medicine Cornus officinalis and Chinese patent medicines containing Cornus officinalis. However, due to the poor stability of morroniside, it is easy to decompose when encountering heat, acid and alkali, resulting in high production and preparation costs, and hindering its use and promotion. [0003] There have been many reports on the preparation method of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/04C07H1/08
Inventor 陈有根常增荣傅欣彤郭洪祝
Owner BEIJING INST FOR DRUG CONTROL
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