Preparation method and application of Xinqin granule

A technology of Xinqin granules and granules, which is applied in the field of preparation of Xinqin granules, and can solve problems such as backwardness, many impurities, and impact on clinical application

Inactive Publication Date: 2015-10-28
赵明亮
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical technology in the extraction and preparation of Xinqin Granules, but the use of water extraction and other methods, the process is rough, complicated, backward, and there are many impurities, resulting in excessive dosage for patients, which is inconvenient to take and seriously affects This product has been applied clinically

Method used

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  • Preparation method and application of Xinqin granule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1: Get asarum 3g, scutellaria baicalensis 10g, Schizonepeta 10g, Angelica dahurica 10g, cassia twig 10g, cocklebur 10g, calamus 10g, astragalus 10g, atractylodes macrocephala 10g, windproof 10g, join CO in the supercritical extractor, Ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 4%, the extraction pressure is 30MPa, the temperature is 30°C, the CO2 flow rate is 1m1 / g crude drug min, and the extraction time is 180min to obtain a supercritical extract, which is pulverized into fine powder. Granulated, prepared into granules, each bag weighing 3g.

Embodiment 2

[0016] Embodiment 2: get asarum 3g, scutellaria baicalensis 10g, Nepeta 10g, Angelica dahurica 10g, cassia twig 10g, cocklebur 10g, calamus 10g, astragalus 10g, Atractylodes macrocephala 10g, windproof 10g, join CO in the supercritical extractor, Ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 15MPa, the temperature is 50°C, the CO2 flow rate is 1m1 / g crude drug min, and the extraction time is 180min to obtain a supercritical extract, which is pulverized into fine powder. Granulated, prepared into granules, each bag weighing 3g.

Embodiment 3

[0017] Embodiment 3: Get Asarum 3g, Scutellaria baicalensis 10g, Nepeta 10g, Angelica dahurica 10g, Guizhi 10g, Fructus Xanthium 10g, Acorus 10g, Radix Astragali 10g, Atractylodes macrocephala 10g, Fangfeng 10g, join CO in the supercritical extractor, Ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 5%, the extraction pressure is 20MPa, the temperature is 40°C, the CO2 flow rate is 2m1 / g crude drug min, and the extraction time is 160min to obtain a supercritical extract, which is pulverized into fine powder. Granulated, prepared into granules, each bag weighing 3g.

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Abstract

Belonging to the field of Chinese medicinal preparations, the invention specifically provides a preparation method of a Xinqin granule. The Xinqin granule is prepared from 3g of Asarum sieboldii, 10g of Scutellaria baicalensis, 10g of Nepeta Cataria, 10g of angelica dahurica, 10g of cassia twig, 10g of Xanthium sibiricum, 10g of Acorus tatarinowii, 10g of Astragalus, 10g of bighead atractylodes rhizome, and 10g of Saposhnikovia divaricata as the crude drugs by supercritical extraction. Therefore, the content is greatly enhanced, and the dosage is reduced. The invention also provides application of the Xinqin granule in preparation of drugs inhibiting human fibrosarcoma HT-1080 proliferation drugs.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of Xinqin Granules. Background technique [0002] Xinqin granules are recorded in the Chinese Pharmacopoeia Standards, the prescription is Asarum 3g, Scutellaria baicalensis 10g, Nepeta 10g, Angelica 10g, Guizhi 10g, Xanthium 10g, Shichangpu 10g, Astragalus 10g, Atractylodes macrocephala 10g, Fangfeng 10g, extracted with water It is prepared by the method of alcohol precipitation, which can strengthen Qi and solidify the surface, expel wind and clear the orifices, and is used for people with insufficient lung qi, nasal itching, sneezing, runny nose, easy cold, and allergic rhinitis caused by the above syndromes. Take it with boiling water, 1 bag at a time, 3 times a day, 20 days as a course of treatment, 20g in each bag. [0003] In the prior art, there is no report on the use of supercritical technology in t...

Claims

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Application Information

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IPC IPC(8): A61K36/888A61K9/16A61P35/00
Inventor 赵明亮
Owner 赵明亮
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