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Application of Cephaloziellin B in preparation of medicine for treating ovarian cancer

A cephaloziellinb, 1. The technology of cephaloziellinb, which is applied in the field of application of cephaloziellinB in the preparation of drugs for the treatment of ovarian cancer, can solve the problems that there is no report on the activity of ovarian cancer

Inactive Publication Date: 2015-11-18
赵东顺
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There is no report on the activity of this compound in the treatment of ovarian cancer

Method used

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  • Application of Cephaloziellin B in preparation of medicine for treating ovarian cancer
  • Application of Cephaloziellin B in preparation of medicine for treating ovarian cancer
  • Application of Cephaloziellin B in preparation of medicine for treating ovarian cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Example 1: Isolation, Preparation and Structure Confirmation of Cephaloziellin B

[0011] The preparation method of Cephaloziellin B is the same as that reported in the literature (Bioactive Limonoid and Triterpenoid Constituents of Turraea pubescens, J. Nat. Prod., 2013, 76, 1166-1174).

[0012] Confirmation of structure: white crystal (methanol), melting point 156-158 °C. According to HR-ESI-MS, the molecular formula is C 20 h 22 o 5 , with an unsaturation of 10. H NMR spectrum data δ H (ppm, DMSO-d 6 , 600MHz): H-1 (2.07, m), H-1 (1.89, dd, J=15.6, 7.2), H-2 (2.42, m), H-2 (2.58, m), H-3 ( 6.91, br, s), H-6 (4.59, dd, J=11.4, 7.8), H-7 (2.28, dd, J=12.5, 7.8), H-7 (1.80, dd, J=12.0), H-10 (1.98, m), H-11 (3.01, dd, J=13.2, 7.8), H-11 (2.00, m), H-12 (5.30, t, J=8.4), H-14 ( 6.47, br, s), H-15 (7.35, br, s), H-16 (7.46, br, s), H-17 (1.20, s), H-19 (1.31, s), H-20 (5.50, s); C NMR spectrum data δ C (ppm, DMSO-d 6 , 600Hz): 19.1 (CH 2 , 1-C), 24.0 (CH 2 , ...

Embodiment 2

[0013] Embodiment 2: Pharmacological action test of Cephaloziellin B

[0014] 1. Materials and Instruments

[0015] The human ovarian serous papillary cystadenocarcinoma cell line SKOV3 was provided by the Medical Experimental Center of Lanzhou University. Common RPMI-1640 medium (10% fetal bovine serum) culture. CephaloziellinB is self-made, and the HPLC normalized purity is greater than 98%. RPMI-1640 culture medium, tetramethylazolidine blue (MTT), dimethyl sulfoxide (DMSO), and L-glutamine were purchased from Kehao Bioengineering Co., Ltd. Trypsin was purchased from Sigma, USA. Fetal bovine serum was purchased from Hangzhou Sijiqing Bioengineering Materials Co., Ltd. Sodium dodecyl sulfonate (SDS) was purchased from Xi'an Zhouding Biotechnology Co., Ltd. HER2 (FITC marker) was purchased from Beijing Boaosen Biotechnology Co., Ltd. Acidified HER2 (FITC-labeled) was purchased from Beijing Boaosen Biotechnology Co., Ltd. Penicillin and streptomycin were purchased from ...

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Abstract

The invention discloses application of Cephaloziellin B in the preparation of a medicine for treating an ovarian cancer, and belongs to the field of medicines. A research shows that the Cephaloziellin B has an inhibition effect on the proliferation of SKOV3 cells of the ovarian cancer, the inhibition rate is concentration-dependent and time-dependent, and the Cephaloziellin B can be further researched and developed to prepare the medicine for treating the ovarian cancer.

Description

technical field [0001] The invention relates to a new application of compound Cephaloziellin B, in particular to the application of Cephaloziellin B in the preparation of drugs for treating ovarian cancer. Background technique [0002] Rui-JuanLi et al. isolated and purified the compound Cephaloziellin B for the first time, and published the results in the famous Natural Products Journal (Secondary Metabolites from the Chinese Liverwort Cephaloziellakiaeri, J.Nat.Prod., 2013, 76, 1700-1708). [0003] At present, there is no report on the activity of this compound in treating ovarian cancer. Contents of the invention [0004] The purpose of the present invention is to provide a medical application of Cephaloziellin B. [0005] The above-mentioned purpose is achieved through the following technical solutions: [0006] Application of CephaloziellinB in the preparation of a drug for treating ovarian cancer, the chemical structural formula of CephaloziellinB is as follows, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/34A61P35/00
Inventor 赵东顺
Owner 赵东顺
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