Cell multidirectional migration experiment device

An experimental and cell technology, applied in the field of multi-directional cell migration experimental devices, can solve the problems of difficulty in comparing migration effects, and difficulty in measuring cell migration rate.

Active Publication Date: 2017-06-27
江苏纽菲尔生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] It is difficult to measure the cell migration rate of different concentrations of chemoattractants on the same cell in the same cell migration experiment; it is also difficult to compare the migration effects of multiple chemoattractants on the same cell

Method used

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  • Cell multidirectional migration experiment device
  • Cell multidirectional migration experiment device
  • Cell multidirectional migration experiment device

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Embodiment Construction

[0036] In order to clearly understand the technical means, creative features, objectives and effects achieved by the present invention, the present invention will be further described below in conjunction with specific drawings.

[0037] Figure 1 to Figure 10As shown, a device for multidirectional cell migration experiments is characterized in that it includes a square chassis 1 with vertical edges around it, and several square combination inserts 2 embedded in the vertical edges of the chassis. Here, several square combinations The number of blocks in the mosaic means that when the cell migration experiment in 8 directions is carried out, there are 9 combined mosaic blocks as shown in Figure 1, and when the cell migration experiment in 4 directions is carried out, there are 5 mosaic blocks as shown in Figure 2 Combined inlays, when carrying out 2 direction cell migration experiments, as shown in Figure 4, there are 3 combined inlays inlaid; the side length of the concave squ...

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Abstract

The invention discloses an apparatus for a cell multidirectional migration experiment, and belongs to an apparatus for cell experiment. The experiment apparatus is characterized by comprising a square chassis which is formed with vertical edges on the periphery, and a plurality of square combined insert blocks embedded in the chassis; the side length of a concave square formed by surrounding the vertical edges of the chassis is equal to three times of the side length of the square combined insert blocks; a cell blind hole is formed in the central combined insert block in the center of the chassis and chemotactic factor blind holes are formed in the peripheral combined insert blocks on the periphery of the central combined insert block, and migration channels are communicated between the blind holes; central distances between the blind holes are equal, and the blind holes are identical to the migration channels in depth; and polymeric filtration membranes are arranged in splicing gaps of the combined insert blocks. After test run, compared with the prior art, the experiment apparatus disclosed by the invention can be used for determining cell migration rates of chemotactic factors differing in concentration level in a same cell migration experiment and can be used for comparing the different migration rates of the various chemotactic factors on a same cell; meanwhile, the experiment apparatus can be used for carrying out a cell penetrating migration experiment; therefore, the experiment apparatus has a more obvious characteristic of flexible combination and splicing in use.

Description

technical field [0001] The invention belongs to a device for cell experiments, in particular to a device for multidirectional cell migration experiments. Background technique [0002] Existing cell migration experimental devices mainly include scratch experimental devices in petri dishes and cell in vitro invasion experimental devices in cups, such as prior art document 1, which is a device for cell migration experiments with publication number CN103952291 A. The technical solution is: "A device for cell migration experiments, which is characterized in that it includes a plate body and holes evenly distributed on the plate body, the holes are set in a square shape, and a grid is arranged outside the bottom of the hole, and the center of the grid is aligned with the hole. The central axis coincides, and there is a separator on the inside of the bottom of the hole", "it can be easily and quickly scratched, and the scratches are neat and consistent in size". Another example is...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12M1/34
CPCC12M23/04C12M29/04C12M41/00
Inventor 孙炳伟王旭沈唯长秦魏婷
Owner 江苏纽菲尔生物医药科技有限公司
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