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Clinic detection kit of multiple biomarkers in ischemic cerebral apoplexy

A detection kit and labeling technology, applied in the field of monitoring the effect of intervention programs, biomarkers, and selecting the combination of biomarkers, can solve the problems of shortening the diagnosis time of ischemic stroke and the like

Inactive Publication Date: 2015-11-25
陈惠 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Provide better diagnostic tools for small and medium-sized hospitals and community health centers that do not have MRI and CT examination equipment at present, shorten the diagnosis time of ischemic stroke, and strive for more opportunities for its treatment, thereby strengthening the three-dimensional diagnosis of stroke. High-level prevention and control measures have a far-reaching impact
The advent of the kit also fills in the lack of specific clinical laboratory diagnostic tools for ischemic stroke (AIS) in China.

Method used

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Embodiment Construction

[0035] The present invention relates to the identification and selection of reagents that are differentially expressed between ischemic stroke patients and normal people from blood and can be used for diagnosis alone or in combination. Thus, the present invention relates to the detection and monitoring of differential protein expression of biomarkers and biomarker combinations for early warning, diagnosis, monitoring, health status evaluation and prediction, and judgment of prognosis and therapeutic effect of ischemic stroke Affordable clinical testing. The invention also relates to methods of identifying particularly useful combinations of biomarkers.

[0036] 1) Definitions The practice of the present invention will employ, unless otherwise indicated, conventional techniques of cell biology, molecular biology, microbiology and recombinant DNA techniques, which are within the skill of the art. Such techniques have been explained in the literature.

[0037] 2) Any combinatio...

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Abstract

The invention relates to SHIP-1, IGF-1, SDPR, MBL, ICAM-1, Hs-CRP, LP(a) and MMP-9 chip clinic diagnosis reagents. Any other combined or single methodological clinic diagnosis reagents except an Hs-CRP biochemical reagent and methodologies are included in claims 1-6. The invention also relates to identification and selection of 8 serum protein markers, identification and selection of any combinations of biomarkers of the 8 serum protein markers, and preparation methods and quality standards of antigens of the 8 serum protein markers, and corresponding antibodies thereof. The 8 serum protein markers are differentially expressed in blood, and can be used for early warning, diagnosis, monitoring, health state evaluation and predication of ischemic cerebral apoplexy diseases, and clinic detection of judgment prognosis and treatment effect evaluation.

Description

1. Technical field: [0001] The present invention relates to identification and selection of multiple and single biomarkers differentially expressed in serum of ischemic stroke and identification and selection of any combination or single marker of differentially expressed biomarkers in serum of ischemic stroke, And methods of selecting said combination of biomarkers. The present invention also relates to the use of biomarkers for early warning, diagnosis, monitoring, health status evaluation and prediction of ischemic stroke diseases, clinical detection and kits for judging prognosis and therapeutic effect parity. The invention also relates to monitoring the effects of intervention programmes. The invention patent belongs to the innovative technology research of the interdisciplinary fields of clinical medicine, emergency medicine, clinical diagnostics, experimental diagnostics and biotechnology. 2. Background technology: [0002] Stroke is one of the most common chronic d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
CPCG01N33/6893G01N2800/2871G01N2800/52
Inventor 陈惠刘小野
Owner 陈惠
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