Solid dispersion of a selective modulator of the progesterone receptor

A solid dispersion, progesterone receptor technology, used in organic active ingredients, sexual diseases, pill delivery, etc.
CN105120899AInactive Publication Date: 2015-12-02LAB HRA PHARMA SA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
LAB HRA PHARMA SA
Publication Date
2015-12-02
Estimated Expiration
Not applicable · inactive patent

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Abstract

The subject matter of the present invention is a solid dispersion comprising an active ingredient chosen from the group consisting of selective modulators of the progesterone receptor, metabolites thereof and mixtures thereof, and a pharmaceutically acceptable polymeric excipient. The invention also relates to a pharmaceutical composition comprising said solid dispersion and to the therapeutic uses thereof.
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Description

technical field

[0001] The present invention relates to novel galenic forms of selective progesterone receptor modulators (SPRMs), more particularly to solid dispersions and pharmaceutical compositions containing said galenical forms. Background technique

[0002] Ulipristal acetate (abbreviated as UPA) corresponds to 17α-acetoxy-11β-[4-(N,N-dimethylamino)phenyl]-19-norpregna-4,9-diene- 3,20-Diketones (IUPAC nomenclature) and have the following chemical formula:

[0003]

[0004] Its synthesis is described inter alia in patent EP0422100 and patent application EP1602662.

[0005] Ulipristal acetate is a synthetic selective progesterone receptor modulator (SPRM). Ulipristal acetate acts as a contraceptive by inhibiting or delaying ovulation by virtue of its action on progesterone receptors. Clinical studies have shown that ulipristal acetate administered in a single dose of 30 mg makes it possible to prevent unwanted pregnancy when administered within 120 hours after unp...

Claims

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