Progestin nano composition and preparation method thereof

A nano-composition, progesterone technology, applied in the direction of drug combination, pharmaceutical formulation, liquid delivery, etc., can solve the problems of poor solubility and bioavailability

Active Publication Date: 2015-12-16
INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, problems such as poor solubility and rapid liver metabolism affect the bioavailability of progesterone orally

Method used

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  • Progestin nano composition and preparation method thereof
  • Progestin nano composition and preparation method thereof
  • Progestin nano composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] Embodiment 1: the preparation of progesterone nanosuspension (1)

[0093] Prescription composition:

[0094]

[0095] Preparation:

[0096] According to the above ratio, at room temperature, two stabilizers, hydroxypropyl cellulose and sodium lauryl sulfate, were dissolved in 60 ml of water, and the resulting aqueous mixture was stirred and mixed at 500 rpm. Progesterone was added to the above mixture under the condition of stirring at 500 rpm, and then stirring was continued at 500 rpm for 10 min. Put the obtained mixture into a wet grinder, rinse the container with 40ml of water, put it into a wet grinder, and grind for 90min at a speed of 1500rpm-4000rpm and a temperature control of 10°C-25°C to obtain a progesterone nanosuspension (1) , wherein the particle size of progesterone nanoparticles is 201.1nm.

Embodiment 2

[0097] Embodiment 2: the preparation of progesterone nanosuspension (2)

[0098] Prescription composition:

[0099]

[0100] Preparation:

[0101] According to the above ratio, at room temperature, two stabilizers, hydroxypropyl cellulose and sodium lauryl sulfate, were dissolved in 60 ml of water, and the resulting aqueous mixture was stirred and mixed at 500 rpm. Progesterone was added to the above mixture under the condition of stirring at 500 rpm, and then stirring was continued at 500 rpm for 10 min. Add the obtained mixture into a wet grinder, rinse the container with 40ml of water, put it into a wet grinder, and grind for 90 minutes at a rotation speed of 1500rpm-4000rpm and a temperature control of 10°C-25°C to obtain a progesterone nanosuspension (2) , wherein the particle size of progesterone nanoparticles is 209.8nm.

Embodiment 3

[0102] Embodiment 3: the preparation of progesterone nanosuspension (3)

[0103] Prescription composition:

[0104]

[0105] Preparation:

[0106] According to the above ratio, at room temperature, two stabilizers, hydroxypropyl methylcellulose and sodium lauryl sulfate, were dissolved in 60 ml of water, and the resulting aqueous mixture was stirred and mixed at 500 rpm. Progesterone was added to the above mixture under the condition of stirring at 500 rpm, and then stirring was continued at 500 rpm for 10 min. Put the obtained mixture into a wet grinder, rinse the container with 40ml of water, put it into a wet grinder, and grind for 90min at a speed of 1500rpm-4000rpm and a temperature control of 10°C-25°C to obtain a progesterone nanosuspension (3) , wherein the particle size of progesterone nanoparticles is 303.7nm.

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Abstract

The invention relates to a progestin nano composition, an applying pellet containing the progestin nano composition, a method for preparing the progestin nano composition and the applying pellet, preparations containing the progestin nano composition and / or the applying pellet such as capsules, tablets and lyophilized powder, and application of the progestin nano composition and the applying pellet on preparation of medicines. The medicines are used for treating and / or preventing diseases caused by hormone deficiency, or are used for hormone replacement therapy after external fertilization.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a progesterone nanocomposition, a drug-containing pellet containing the progesterone nano-composition, a method for preparing the progesterone nano-composition and a drug-based pellet, and a corpus luteum Preparations of ketone nanocomposites and / or drugged pellets, such as capsules, tablets or freeze-dried powders, and the use of the progesterone nanocomposites and drugged pellets in the preparation of medicines, which are used to treat And / or to prevent diseases caused by corpus luteum deficiency, or for hormone replacement therapy after in vitro fertilization. Background technique [0002] Progesterone is a natural progesterone secreted by the corpus luteum of the ovary during the luteal phase. It can also be produced by the placenta and adrenal gland. Its chemical name is pregna-4-ene-3,20-dione. It was first synthesized in 1934. sell. [0003] The pharmacological effects of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K31/57A61K47/38A61K9/16A61K9/48A61K9/20A61K9/19A61J3/00A61K47/32A61K47/36A61K47/26A61K47/20A61K47/14A61K47/18A61P15/00A61P15/06A61P5/34
Inventor 郑爱萍郑敏杰孙建绪陈杰应明华王咏葛强
Owner INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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