A lncrna marker and kit for schizophrenia diagnosis

A technology for schizophrenia and diagnostic kits, applied in DNA/RNA fragments, recombinant DNA technology, biochemical equipment and methods, etc., can solve problems such as reducing the stability of target mRNA, achieve high diagnostic reference value, and improve diagnostic accuracy efficiency, simplifying the diagnostic process

Inactive Publication Date: 2019-02-15
中国人民解放军联勤保障部队第九〇四医院
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  • Abstract
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AI Technical Summary

Problems solved by technology

lncRNAs can regulate mRNA stability, for example, TINCR increases its stability by interacting with FLG, LOR, ALOXE3, ALOX12B, ABCA12, CASP14 or ELOVL3, while some lncRNAs can decrease the stability of their target mRNAs

Method used

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  • A lncrna marker and kit for schizophrenia diagnosis
  • A lncrna marker and kit for schizophrenia diagnosis
  • A lncrna marker and kit for schizophrenia diagnosis

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Embodiment Construction

[0030] 1. Research object

[0031] This study was approved by the Medical Ethics Committee of the 102nd Hospital of the Second Military Medical University Clinical Hospital of the Chinese People's Liberation Army, and all subjects or their family members (guardians) signed the informed consent.

[0032]1. Case group: From August 2012 to June 2014, patients were continuously admitted to the outpatient department and psychiatric ward of the 102nd Hospital of the People's Liberation Army. Inclusion criteria: ①Meet the diagnostic criteria for schizophrenia in the 4th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV); ②First-episode patients or did not take antipsychotic drugs 3 months before enrollment; ③Age between 15 and 80 years old. Exclusion criteria: ① suffering from other mental diseases; ② suffering from physical or nervous system diseases such as traumatic brain injury; ③ having a history of alcoholism or drug abuse; ④ having a history of blood...

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Abstract

The invention belongs to the technical field of biology, and relates to an IncRNA marker for schizophrenia diagnosis and a kit. The invention provides the IncRNA marker for schizophrenia diagnosis. The IncRNA marker comprises NONHSAT089447, NONHSAT021545 and NONHSAT041499. The primer sequences of the three kinds of IncRNA are shown as SEQ ID NO.1 to SEQ ID NO.6. The invention also provides a probe used for the three kinds of IncRNA. The probe sequence is shown as SEQ ID NO.7 to SEQ ID NO.9. The IncRNA marker has the beneficial effect that a schizophrenia biological marker and a biological marker for evaluating curative effects of psychosis-resistant medicine are provided for the first time. Clinical result proves that the IncRNA marker has higher specificity and sensitive value, and has a higher diagnosis reference value. The IncRNA can bring the revolutionary change to the schizophrenia diagnosis and treatment as the schizophrenia specific biological marker.

Description

technical field [0001] The invention belongs to the field of biotechnology, and relates to an lncRNA marker and a kit for schizophrenia diagnosis. Background technique [0002] Schizophrenia (SZ) is one of the most serious mental disorders, with positive symptoms such as hallucinations, delusions, and psychomotor excitement and / or negative symptoms such as blunt affect, apathy, social withdrawal, and decreased will. A clinical feature that causes severe impairment of the patient's cognitive, emotional, behavioral, and social functioning. [0003] At present, although there is a certain understanding of the etiology of SZ, researchers have studied the etiology of SZ based on techniques such as neuroimaging, genomics, proteomics, and immunohistochemistry. The results involve genetic factors, social psychological factors, and neurobiochemical factors. Pathological theory, brain pathology and brain structure change theory, etc. However, there is still a lack of sufficient unde...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6883C12N15/11
CPCC12Q1/6886C12Q2600/158C12Q2600/178
Inventor 张理义
Owner 中国人民解放军联勤保障部队第九〇四医院
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