The invention belongs to the field of biotechnology, and relates to a schizophrenia biomarker, a detection method and a kit. The invention provides a schizophrenia biomarker, a detection method thereof and a kit for detecting the content of the biomarker, wherein the biomarker comprises miRNA-30e, miRNA-181b, miRNA-346, miRNA-34a and miRNA-7. The invention further provides a schizophrenia outcome biomarker, a detection method of the marker, and a kit for detecting the content of the marker, wherein the schizophrenia outcome biomarker comprises miRNA-30e, miRNA-181b, miRNA-132 and miRNA-432. The beneficial effects are of providing the biomarker for the diagnosis and outcome of the schizophrenia, the biomarker has higher specificity and higher diagnosis reference values.