Schizophrenia marker

A technology of markers and microorganisms, applied in the field of biomarkers of schizophrenia, to achieve good diagnostic efficiency

Inactive Publication Date: 2018-03-02
张猛 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are currently no biomarkers or combination tests to assess the diagnosis, prognosis, or prediction of response to treatment in schizophrenia

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1 Basic Example: Acquisition of Markers

[0032] 1. Enroll in healthy group and schizophrenia patient group:

[0033] Referring to the standards implemented by NIH for "healthy people", some items were slightly supplemented, and local residents in Huludao, Liaoning, northeast China were screened. The criteria are as follows: 1) Han Chinese, local residents of Huludao, and no special religious beliefs; 2) Age between 18-65 years old; 3) Body mass index between 18-35; 4) No chronic diseases and diseases that may affect the stability of intestinal flora, such as: hypertension, diabetes, immunodeficiency disease, Autoimmune diseases, cancer, inflammatory bowel disease (IBD), diarrhea in the past 3 months, etc.; 5) No special medication history in the past 6 months, including: antibiotics, glucocorticoids, cytokines, and large doses of probiotics and biological agents; 6) No gastroscopy, colonoscopy, gastrointestinal barium meal and other examinations; 7) No history...

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PUM

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Abstract

The invention relates to the fields of genetic engineering and biomedicine, and more specifically relates to a biomarker of schizophrenia and its application. The invention discloses a marker of schizophrenia and its application in preparing a kit for diagnosing schizophrenia, and also discloses a kit for detecting the marker. The schizophrenia markers disclosed in the present invention include Prevotella, Succinivibrio, Fusobacterium, Lactobacillus, and Megasphaera , Acidaminococcus, Citrobacter, Phascolarctobacterium, Coprococcus, Roseburia, Blautia 11 species At least 5 of the microorganisms. The marker provided by the invention can judge schizophrenia and normal people, the AUC is above 0.81, has good diagnostic efficiency, and can be used to prepare a kit for effectively diagnosing schizophrenia.

Description

technical field [0001] The invention relates to the fields of genetic engineering and biomedicine, and more specifically relates to a biomarker of schizophrenia and its application. Background technique [0002] Schizophrenia is a common severe mental illness with a lifetime prevalence rate of 0.16-1.21%, with age and gender differences. Most of the onsets are in young adults, and there are often obstacles in perception, thinking, emotion, and behavior, as well as incoordination between mental activities and the environment. The course of the disease is often protracted, and generally there is no intellectual disability. Schizophrenic patients account for about half of the hospitalized mental patients in my country. The disease has a serious impact on the physical and mental health of patients, and also brings a serious social burden, resulting in huge economic and social pressure, and the resulting medical expenses are also huge. [0003] The etiology of schizophrenia rem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/04C12Q1/6883G01N33/569G01N27/62
CPCC12Q1/04C12Q1/6883C12Q2600/118G01N27/62G01N33/56911G01N2800/302
Inventor 张猛梁英
Owner 张猛
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