Biomarker of schizophrenia and usage method and application thereof

A schizophrenia, material technology, applied in the medical field, can solve the problems of economic burden, long-term recurrent attacks, etc.

Inactive Publication Date: 2014-01-15
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

While some patients recover with treatment, most suffer from recurrent episodes over a long period of time, making schizophrenia not only an individual disease but also a serious social problem with consequences for families, the health care system and society at large obvious financial burden

Method used

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  • Biomarker of schizophrenia and usage method and application thereof
  • Biomarker of schizophrenia and usage method and application thereof
  • Biomarker of schizophrenia and usage method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0135] After the sample is analyzed by GC-TOFMS, a three-dimensional data structure is obtained, including sample number, peak retention time and peak area. The total ion chromatograms of typical schizophrenic patients and healthy controls are shown in figure 1 . Noise will be generated during high-throughput mass spectrometry analysis, the retention time of the same substance in each sample may shift, and the conditions of the chromatographic column will also change after a long period of work. Therefore, the data needs to undergo operations such as denoising and peak matching to make the variables between samples comparable. Some metabolites produce different derivatives in the TMS derivatization operation, so that they appear at different retention times. This requires firstly identifying the metabolites based on the mass spectrum fragments, and then combining the peak areas of the same substance and reducing it into one variable for analysis. The content distribution of ...

Embodiment 2

[0151] Example 1 was repeated, but utilizing 3-hydroxybutyric acid, glyceric acid, and cysteine ​​each, and combinations of any two of them.

[0152] The linear equations used for diagnosis are all constructed in the model training set using logistic regression, where "P" represents the probability of disease, 1 is diseased, 0 is not diseased; "c (metabolite)" represents the metabolic rate The measured serum levels of the substance.

[0153] The diagnostic specificity / sensitivity lookup tables for each diagnostic marker and their pairwise combinations were obtained based on all samples, and the specific lookup table is shown below.

[0154] Table 4. Diagnostic specificity / sensitivity query table for 3-hydroxybutyrate alone

[0155] Y=c(3-hydroxybutyric acid)

[0156]

[0157]

[0158]

[0159]

[0160] Table 5. Diagnostic specificity / sensitivity query table for glyceric acid alone

[0161] Y=c (glyceric acid)

[0162]

[0163]

[0164]

[0165]

[0...

Embodiment 3

[0207] According to the criteria described in the "Materials and Methods" section, 40 patients with schizophrenia in Wuhu and 40 controls were selected; the above samples were subjected to double-blind detection, and 3-hydroxybutyric acid, glyceric acid and cysteine ​​were detected in the above samples Then use the linear equation and the threshold provided by Examples 1 and 2 to diagnose whether the test subject suffers from schizophrenia.

[0208] result:

[0209] The serum content of 3-hydroxybutyric acid alone is used as a diagnostic marker, and the detection accuracy is 0.7125 (sensitivity is 0.525, specificity is 0.9, threshold is 28700); single use glyceric acid, the detection accuracy is 0.7625 (sensitivity is 0.7, the specificity is 0.825, and the threshold is 4070); with cysteine ​​alone, the detection accuracy is 0.7 (the sensitivity is 0.65, the specificity is 0.75, and the threshold is 3820).

[0210] When 3-hydroxybutyric acid and glyceric acid are combined as ...

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Abstract

The invention discloses a group of biomarkers for diagnosis of schizophrenia, and the biomarkers can be applied to preparation of detection reagents or detection kits for diagnosis of schizophrenia. Based on the markers, the invention also provides a detection kit, a detection reagent and a chip or array for the diagnosis of schizophrenia, and a method for the diagnosis of schizophrenia by using the markers. The method of the present invention is simple and practical, has reliable diagnosis results and gives consideration to both sensitivity and specificity.

Description

technical field [0001] The present invention relates to the field of medicine. In particular, the present invention relates to biomarkers for schizophrenia, methods of use and applications thereof. Background technique [0002] Schizophrenia is a common mental illness with a prevalence of 0.3%-0.7% in the global population [1]. Schizophrenia usually occurs in young and middle-aged adults, and there are often obstacles in perception, thinking, emotion, and behavior, as well as incoordination of mental activities, which seriously affect the patient's physical function and quality of life. While some patients recover with treatment, most suffer from recurrent episodes over a long period of time, making schizophrenia not only an individual disease but also a serious social problem with consequences for families, the health care system and society at large obvious financial burden. [0003] At present, the clinical diagnosis of schizophrenia is mainly based on the patient's de...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N27/64
Inventor 贺林万春玲孙丽雅杨景雷贾伟
Owner SHANGHAI JIAO TONG UNIV
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