Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of andrographolide dry suspension and preparation method thereof

A technology of andrographolide, dry suspension, applied in the directions of antiviral agents, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve problems such as unfavorable patients taking medicine, insoluble in water, and andrographolide taste bitter, etc. , to achieve the effect of no bitterness, good taste and convenient taking.

Active Publication Date: 2018-07-27
JIANGZI QINGFENG PHARMACEUTICALS INC
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, andrographolide has developed common dosage forms such as tablets, capsules, and dripping pills. However, diterpenoid lactone compounds are difficult to dissolve in water and can only be administered orally
In addition, due to the extremely bitter taste of andrographolide, it is unfavorable for children, the elderly and patients with dysphagia to take medicine. These dosage forms have not solved this problem

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of andrographolide dry suspension and preparation method thereof
  • A kind of andrographolide dry suspension and preparation method thereof
  • A kind of andrographolide dry suspension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Take 30g of stearyl alcohol in a beaker, heat the beaker in a water bath at 85°C, and after it melts, add 10g of andrographolide and stir with a magnetic stirrer for 30 minutes, so that the andrographolide is mixed with the suspension in the stearyl After soaking in alcohol, hot melt spray granulation is carried out.

[0043] The melt spray parameters are: air inlet temperature 130°C, atomization pressure 0.3Kpa, feed rate 80ml / min.

[0044] The hot-melt spray product is collected to obtain the flavored mixture of andrographolide. The mixture is mixed with fillers, flavoring agents, sweeteners, sour agents and suspending agents in appropriate proportions to obtain the andrographolide dry suspension.

[0045] The prescription of andrographolide dry suspension is as follows:

[0046] Mixture of andrographolide and stearyl alcohol: 4g

[0047] Lactose: 15.3g

[0048] Xanthan gum: 0.1g

[0049] Micropowder silica gel: 0.05g

[0050] Neotame: 0.2g

[0051] Sweet orang...

Embodiment 2

[0056] Take 30g of glyceryl monostearate in a beaker, seal it with plastic wrap, heat the beaker in a water bath at 85°C, and after it melts, add 10g of andrographolide and stir with a magnetic stirrer for 30 minutes to make the Andrographis paniculata After the esters were suspended in stearyl alcohol, hot-melt spray granulation was carried out.

[0057] The prescription of andrographolide dry suspension is as follows:

[0058]Mixture of andrographolide and glyceryl monostearate: 4g

[0059] Starch: 15.3g

[0060] Xanthan gum: 0.1g

[0061] Micropowder silica gel: 0.05g

[0062] Neotame: 0.2g

[0063] Sweet orange essence: 0.2g

[0064] Citric acid: 0.2g

[0065] The melt spray parameters are: air inlet temperature 130°C, atomization pressure 0.3Kpa, feed rate 80ml / min.

[0066] The hot-melt spray product is collected to obtain the flavored mixture of andrographolide. . The mixture is mixed with fillers, flavoring agents, sweeteners, sour agents and suspending agents...

Embodiment 3

[0070] Take 10g of stearyl alcohol and 10g of glyceryl monostearate in a beaker, seal it with plastic wrap, heat the beaker in a water bath at 85°C, after it melts, add 10g of andrographolide, and stir with a magnetic stirrer for 30 Minutes, so that the andrographolide was suspended in stearyl alcohol, and then hot-melt spray granulation was carried out.

[0071] The melt spray parameters are: air inlet temperature 130°C, atomization pressure 0.3Kpa, feed rate 50 / min.

[0072] The hot-melt spray product is collected to obtain the flavored mixture of andrographolide. The mixture is mixed with fillers, flavoring agents, sweeteners, sour agents and suspending agents in appropriate proportions to obtain the andrographolide dry suspension.

[0073] The prescription of andrographolide dry suspension is as follows:

[0074] Mixture of andrographolide with stearate and glyceryl monostearate: 4g

[0075] Lactose: 15.3g

[0076] Sodium alginate: 0.1g

[0077] Micropowder silica gel...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses an andrographolide dry suspension and a preparation method thereof. The dry suspension is particles prepared from andrographolide and auxiliary materials through mixed spraying, wherein the auxiliary materials comprise one auxiliary material which has a relatively low melting point, and is 0.1-10 times of the mass of the andrographolide, and further comprise at least one other auxiliary. The andrographolide dry suspension can be taken with a small amount of water, is convenient to take, has little bitter taste, has a good effect of modifying the taste of andrographolide, and is suitable for children, old people and patients with swallow difficulty.

Description

Technical field: [0001] The invention relates to a dry suspension of andrographolide and a preparation method thereof. Background technique: [0002] Whether it is a chemical medicine or a traditional Chinese medicine, the bitter taste of the medicine is one of the reasons why it is not accepted by people. Andrographolide is a diterpene lactone compound, which has the effects of dispelling heat and detoxification, reducing inflammation and relieving pain, and is effective against bacteria and viruses. It has a special curative effect on upper respiratory tract infection and dysentery, and is known as a natural antibiotic drug. In recent years, andrographolide has been developed into common dosage forms such as tablets, capsules, and dripping pills. However, diterpenoid lactone compounds are difficult to dissolve in water and can only be administered orally. In addition, because the taste of andrographolide is extremely bitter, it is unfavorable for children, the elderly and...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K31/365A61P31/04A61P31/12A61P11/00A61P1/12
CPCA61K9/1617A61K9/1652A61K31/365
Inventor 罗晓健杨小玲吕武清简辉李志勇崔刚饶小勇张尧刘尧奇汤新乾田佳明朱文涛王章伟王振
Owner JIANGZI QINGFENG PHARMACEUTICALS INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com