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Biological edge mark system and establishing method thereof

A technique for establishing methods and labels for applications in computational systems biology and bioinformatics

Inactive Publication Date: 2016-05-18
SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
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  • Biological edge mark system and establishing method thereof
  • Biological edge mark system and establishing method thereof
  • Biological edge mark system and establishing method thereof

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[0052] The above-mentioned features and advantages of the present invention can be better understood after reading the detailed description of the embodiments of the present disclosure in conjunction with the following drawings. In the drawings, components are not necessarily drawn to scale, and components with similar related properties or characteristics may have the same or similar reference numerals.

[0053] figure 1 The flowchart of the first embodiment of the establishment method of the bio-edge identification system of the present invention is shown. See figure 1 The implementation steps of the method for establishing the bio-edge identification system in this embodiment are as follows.

[0054] Step S11: Collect data with two states.

[0055] Data with dual states include: normal state data and disease state data, transfer state data and non-metastatic state data, data with drug resistance state and data without drug resistance state. The data types of data with t...

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Abstract

The invention discloses a biological edge mark system and an establishing method thereof, which can simply and efficiently find out a key interactive change as a biological marker of disease occurrence and development. The technical scheme provided by the invention is as follows: the establishing method of the biological edge mark system comprises the steps: collecting data with double states; selecting gene pairs, the correlation of which meets significant difference conditions; for the gene pairs, the correlation of which meets the significant difference conditions, translating expression value data of the gene pairs into edge data representing the correlation through matrix transformation; applying a feature selection algorithm to find out a gene pair with the optimal classification capacity from the edge data, and utilizing the gene pair with the optimal classification capacity as a biological edge mark, thereby establishing a biological edge mark system.

Description

technical field [0001] The invention relates to computational system biology and bioinformatics, in particular to a method and a system for processing biomarkers. Background technique [0002] The study of biomarkers has always been an important topic in the field of biomedicine. A successful biomarker can help doctors make an accurate diagnosis or propose an effective treatment plan. Therefore, finding a suitable biomarker is very important for overcoming diseases, especially complex diseases. significance. [0003] Human complex diseases are a general term for a class of diseases with unclear etiology, many factors involved, and no effective treatment, such as various types of cancer and diabetes. Since the 1980s, the rapid development of high-throughput biotechnology (such as DNB chips, high-throughput sequencing, etc.) has brought opportunities for the study of complex human diseases. [0004] How to find useful biomarkers from the massive data generated by these techn...

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Application Information

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IPC IPC(8): G06F19/10
Inventor 陈洛南张万纬
Owner SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
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