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A Method of Intensity Modulated Subfield Optimization Based on Gradient Method and Flood Fill Method

A flood filling and optimization method technology, which is applied in radiation therapy, X-ray/γ-ray/particle irradiation therapy, treatment, etc., to meet user needs, quickly and efficiently optimize the intensity-modulated sub-field, and achieve important industrial application value.

Inactive Publication Date: 2018-03-27
HEFEI INSTITUTES OF PHYSICAL SCIENCE - CHINESE ACAD OF SCI
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Problems solved by technology

[0004] Problems solved by the technology of the present invention: In order to overcome the deficiencies of the prior art, the object of the present invention is to provide an intensity modulated subfield optimization method based on the gradient method and flood filling method, which can quickly and effectively solve the problem of intensity modulated subfield optimization. The optimization results can fully meet the requirements of radiotherapy planning, and the calculation time can be within the range acceptable to those skilled in the art

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  • A Method of Intensity Modulated Subfield Optimization Based on Gradient Method and Flood Fill Method
  • A Method of Intensity Modulated Subfield Optimization Based on Gradient Method and Flood Fill Method
  • A Method of Intensity Modulated Subfield Optimization Based on Gradient Method and Flood Fill Method

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Embodiment Construction

[0021] like figure 1 As shown, the present invention is realized as:

[0022] (1) Initialize the subfield shape, as follows:

[0023] According to the dose calculation, the dose contribution matrix D of each pencil beam in the kth field to the sampling point in the target area is obtained k , get the matrix S by formula (1) k,1 .

[0024]

[0025] In the formula, ε is a constant, which generally takes a value of 0.001, and (i,j) represents row i and column j. S k,1 As the first initial subfield shape of the kth field.

[0026] (2) Use the gradient method to optimize the subfield weight and calculate the intensity gradient on the field, as follows:

[0027] After obtaining the initial subfield shape in each field direction, the corresponding subfield weights are optimized using the gradient method. Make the dose value of each organ sampling point after accelerator irradiation meet the organ dose constraint given by the doctor as far as possible. The objective functio...

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Abstract

The invention provides an intensity-modulated sub-field optimization method based on the gradient method and the floodfill algorithm. The method comprises steps of firstly establishing an optimization model according to conditions of information of targets and endangered organs, beam parameters and dosage (size) constraints and initializing an initial sub-field of each radiation field; secondly, by adopting the gradient method, optimizing sub-field weight and obtaining an intensity gradient on a radiation field; thirdly, based on the intensity gradient, by using the floodfill algorithm, calculating a new sub-field shape of the corresponding radiation field; and at last, returning to the step 2 until existing the optimization. According to the invention, solving speed is quick; optimization effects are favorable; the algorithm is stable; and robustness is high.

Description

technical field [0001] The invention relates to an intensity-modulated subfield optimization method based on a gradient method and a flood filling method, and belongs to the technical field of intelligent computing methods. Background technique [0002] Static intensity-modulated radiotherapy is currently the most commonly used treatment method in clinical practice. In general, the field intensity that meets the desired dose distribution in each direction is optimized first, and then the intensity is segmented into subfields, which can be converted into dynamic multi-leaf grating. This method is called "two-step method" for short. When optimizing the intensity distribution, it is difficult or not to consider the hardware constraints of the dynamic multi-leaf grating, and this kind of constraints can only be considered in the sub-field segmentation, resulting in a large number of sub-fields after the sub-field segmentation, which greatly improves the Treatment time increases...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61N5/10
CPCA61N5/1031
Inventor 裴曦吴宜灿胡丽琴曹瑞芬汪冬
Owner HEFEI INSTITUTES OF PHYSICAL SCIENCE - CHINESE ACAD OF SCI
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