Human brain regional water distribution volume measurement method using cerebral gray matter as reference area

A measurement method and water distribution technology, applied in the field of biological and medical imaging, can solve problems such as insufficient accuracy, achieve good application scenarios, and facilitate automatic processing

CN105748093BActive Publication Date: 2018-11-16上海蓝生脑科医学研究有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Publication Date
2018-11-16

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Abstract

The invention discloses a human brain local water distribution volume determining method taking cerebra gray matter as a reference region. The method is characterized by comprising the following steps that 1, PET / H2<15>O dynamic scanning is conducted on a human brain; 2, the cerebra gray matter of the human brain serves as the reference region, and a relative water distribution volume value P1 of each part to be calculated in the brain is calculated; 3, after the relative water distribution volume value P1 of each part of the human brain is calculated, normalization is conducted on the human brain according to needs; the obtained value only differs by a proportional constant from the absolute water distribution volume of the part, and the obtained value serves as an index of the absolute water distribution volume. According to the human brain local water distribution volume determining method taking the cerebra gray matter as the reference region, the arterial blood does not need to be dynamically drawn, a template or a model which is probably distorted is not needed, manual interventions such as complex modification are not needed, and therefore automated processing of a computer is achieved conveniently. Meanwhile, a deviation does not exist between the determined result and the result obtained through an accurate local water distribution volume quantitative determination method, and a good application prospect is achieved.
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Description

technical field

[0001] The invention relates to a method for measuring the local water distribution volume of the human brain, in particular to a method for measuring the local water distribution volume of the human brain using the gray matter of the brain as a reference area. The invention belongs to the field of biological and medical imaging. Background technique

[0002] Using Positron Radionuclides 15 O labeled water (i.e. H 2 15 O) Positron Emission Tomography (PET) method (abbreviated as PET / H) as imaging agent 2 15 O method) is to carry out PET dynamic scanning after intravenous injection of H2O, and then use the Kety-Schmidt single-chamber model (see Kety SS. (1951) The theory and applications of the exchange of inert gas at the lungs and tissues. Pharmacol Rev 3: 1-41.) and other methods to quantitatively calculate the local water distribution volume pixel by pixel, so that the image of the local water distribution volume can be generated.

[0003] In the ear...

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Embodiment Construction

[0023] The present invention will be specifically introduced below in conjunction with the accompanying drawings and specific embodiments.

[0024] refer to figure 1 As shown, the method for measuring the local water distribution volume of the human brain with the gray matter of the brain as the reference area of ​​the present invention is a PET / H method of the local water distribution volume of the human brain. 2 15 O non-invasive quantitative measurement method, which can quantitatively measure the human brain pixel by pixel, and then generate functional images of the local water distribution volume of the human brain. In order to realize the above-mentioned purpose of the invention, the present invention is achieved by taking the following technical solutions:

[0025] The method for quantitatively measuring the volume of distribution of human brain local water as a reference area in the gray matter of the brain is characterized in that:

[0026] (1) PET / H for human brai...