Medicine for treating asthma and kidney qi deficiency, animal model and establishing and using method

Abstract

The invention discloses a medicine for treating asthma and kidney qi deficiency, an animal model and an establishing and using method. The medicine for treating asthma and kidney qi deficiency is prepared from 12g of prepared rehmannia roots, 12g of pulp of dogwood fruit, 12g of rhizoma dioscoreae, 12g of rhizoma alismatis, 12g of radix sophorae flavescentis, 12g of Japanese metaplexis pericarp, 12g of tree peony bark, 12g of poria cocos, 5g of schisandra chinensis, 8g of agilawood pieces, 15g of inula flowers, 15g of indigo naturalis and clam powder and 15g of raw radix astragalis. In the early period, a kidney qi deficiency and asthma symptom combined rat model is established, and it is observed that kidney tonifying and asthma relieving soup and glucocorticoid can correct Th1/Th2 unbalance by adjusting expression of transcription factors. Specificity transcription factors, key cell factors and tiny RNA of a T cell subset serve as indexes, an internal mechanism of kidney qi deficiency asthma attacking and Treg/Th balance is proved, and a multi-target-point multi-layered network type regulatory mechanism possibly existing in traditional Chinese medicine for treating asthma is disclosed.

Description

technical field [0001] The invention belongs to the field of medical technology, and in particular relates to a medicine for treating asthma with kidney-qi deficiency, an animal model and a method for constructing and using it. Background technique [0002] Bronchial asthma (Bronchial asthma, referred to as asthma) is one of the most common chronic diseases in the world, affecting up to 10% of adults and 30% of children in Western countries. There are currently about 300 million asthmatic patients in the world, and the prevalence rate is increasing at a rate of about 1% per year, seriously affecting the daily life and work of patients, and bringing heavy burdens to families and society. Therefore, in-depth research on asthma has become a global issue today. important topics. [0003] As a heterogeneous disease, bronchial asthma has complex and diverse pathogenesis. In recent years, the discovery of regulatory T cells (Treg) and helper T cells 17 (Th17) has corrected the tr...

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Problems solved by technology

[0008] The purpose of the present invention is to provide a drug for the treatment of asthma with kidney-qi deficiency, an animal model and a method for constructing and using it, aiming at solving t...

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