Pharmaceutical compositions comprising 15-hepe and methods of treating asthma and lung disorders using same

A technology of 15-HEPE and composition, applied in the field of composition containing 15-HEPE, which can solve the problems of low-efficiency delivery, limited dosage strength, etc.

Inactive Publication Date: 2016-10-12
AFIMMUNE LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these drugs are not always effective in reducing symptoms, slowing progression, or reversing the course of clinical manifestations of the condition
Furthermore, current regimens are limited in dose strength due to side effects and are limited by inefficient delivery to the subject's lungs

Method used

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  • Pharmaceutical compositions comprising 15-hepe and methods of treating asthma and lung disorders using same
  • Pharmaceutical compositions comprising 15-hepe and methods of treating asthma and lung disorders using same
  • Pharmaceutical compositions comprising 15-hepe and methods of treating asthma and lung disorders using same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0096] Example 1: In vivo histamine-induced bronchoconstriction after long-term exposure to 15-HEPE in guinea pigs internal research

[0097] Guinea pigs are a reliable animal model in respiratory research due to their airway sensitivity and the fact that they exhibit an airway response similar to that observed in humans. Guinea pigs have a well-developed bronchial smooth muscle compartment, which is indispensable for the purposes of this study.

[0098] This study design was based on the current International Conference on Harmonization (ICH) Tripartite Harmonization Guidelines (ICH S7A) and generally accepted procedures for testing pharmaceutical compounds.

[0099] Adult male Hartley guinea pigs weighing approximately 450-500 g are acclimated for a minimum of 5 days prior to the date of initiation of oral gavage. Animals were assigned to one of four groups (low dose, high dose, vehicle, and positive control) and double housed during the acclimatization phase.

[0100]...

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PUM

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Abstract

The disclosure provides compositions comprising 15-HEPE or derivatives thereof used singly or in combination with other active agents for the treatment and/or prevention of lung diseases and disorders such as asthma.

Description

[0001] Cross References to Related Applications [0002] This application requires the title of "Pharmaceutical Compositions Comprising 15-OHEPA and Methods of Using It to Treat Asthma and Lung Disorders (PHARMACEUTICAL COMPOSITIONS COMPRISING 15-OHEPA AND METHODS OF TREATINGASTHMA AND LUNG DISORDERS USING SAME)" submitted on January 10, 2014 The benefit of U.S. Provisional Patent Application No. 61 / 926,052, the contents of which are hereby incorporated by reference in their entirety. technical field [0003] The present disclosure generally relates to compositions comprising 15-HEPE, alone or in combination with other active agents, for the treatment and / or prevention of asthma and pulmonary disorders. Background technique [0004] Lung diseases and disorders, such as asthma and COPD, affect millions of people worldwide. [0005] Asthma is a chronic lung disease that inflames and narrows the airways. The narrowing of the airways is the result of muscle tightening and inf...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/36A61K31/202A61K31/327A61K8/38A61K9/00
CPCA61K31/202A61K45/06A61P11/00A61P11/06A61P11/08A61P11/10A61P43/00A61P5/40A61K2300/00A61K31/327
Inventor M·曼库J·克莱麦克斯K·达菲
Owner AFIMMUNE LTD
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