Urethra prosthesis reconstructing method based on 3D printing forming

A urethral prosthesis, 3D printing technology, applied in artificial cell constructs, biochemical equipment and methods, epidermal cells/skin cells, etc., can solve the problems of patients and their families, and achieve the effect of simple and easy technical means

Inactive Publication Date: 2016-11-09
SOUTH CHINA UNIV OF TECH
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  • Application Information

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Problems solved by technology

There are many complications such as urinary fistula and stenosis in traditional operations, and som

Method used

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  • Urethra prosthesis reconstructing method based on 3D printing forming
  • Urethra prosthesis reconstructing method based on 3D printing forming

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Embodiment

[0019] Such as figure 1 , figure 2 shown. The invention discloses a method for reconstructing a urethral prosthesis based on 3D printing, comprising the following steps:

[0020] Step 1: Adipose-derived stem cells are extracted, differentiated into epithelial-like cells and smooth muscle-like cells by cell-inducing factors, and then transformed into cell droplets, which are mixed with cells and culture fluid hydrogel to make available Bio-inks3 for use in medical 3D printers2;

[0021] Step 2: Select the hydrogel mixed with collagen and alginate as the scaffold ink 4 of the scaffold material, and put the scaffold ink 4 and the bio-ink 3 into the respective material storage tanks of the dual-nozzle 3D printer;

[0022] Step 3: Computer 1 controls cells or cell aggregates, the ratio between cells and gels, and the injection position and force of nozzles through computer 1 through the obtained urethra scale data, and controls the lifting and lowering of nozzles with an electr...

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Abstract

The invention discloses a urethra prosthesis reconstructing method based on 3D printing forming. The method comprises the steps that adipose-derived stem cells are differentiated into epithelioid cells and smooth muscle-like cells through cell inducing factors and then converted into cell liquid drops, and the cell liquid drops are prepared by mixing the cells with culture liquid hydrogel and prepared into biological ink capable of being used by a 3D printer; hydrogel prepared by mixing collagen with alginate is selected as stent ink of a stent material; the cells or cell clusters, the proportion of the cells to the gel and the jetting positions and strength of nozzles are controlled by a computer, two spray heads are controlled by an electronically-controlled lifting platform to go up and down, and the urethra section is alternately printed by the two spray heads of the 3D printer layer by layer. According to the method, the adipose-derived stem cells are cultured in vitro, induced to be differentiated into the urothelial cells and the smooth muscle cells and then converted into the cell liquid drops, the urethra is reconstructed in vitro by combining 3D printing, then the reconstructed urethra is transplanted into the body of a patient, and therefore the urethra reconstruction problem is solved.

Description

technical field [0001] The invention relates to the preparation of a urethral prosthesis, in particular to a method for reconstructing a urethral prosthesis based on 3D printing. Background technique [0002] The etiology and condition of urethral diseases are complicated, and the incidence rate is high. The related urethral reconstruction surgery is difficult and risky, and the technical mastery of urethral reconstruction in various hospitals is not balanced. Urethral diseases that often require urethral repair or reconstruction include: urethral stricture and congenital urethral malformations. Urethral strictures have varying prevalence worldwide. The main cause of urethral stricture in my country is trauma, such as pelvic fracture, blunt perineal injury; the second most common cause of urethral stricture is urethral stricture caused by various medical procedures, such as indwelling catheterization, open prostatectomy, After urethral surgery, hypospadias. Traditional ope...

Claims

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Application Information

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IPC IPC(8): C12N5/071B29C67/00B33Y10/00
CPCC12N5/0697B33Y10/00C12N2502/1347C12N2502/09C12N2533/74C12N2533/54
Inventor 文尚胜史晨阳
Owner SOUTH CHINA UNIV OF TECH
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