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Complex probiotic preparation for reducing 5-hydroxytryptamine side effects after chemotherapy

A technology of compound probiotics and side effects, applied in medical preparations containing active ingredients, digestive system, drug combination, etc., can solve the problem of increased mortality of cancer patients, achieve good ecological mutual assistance, high safety, reduce patient painful effect

Pending Publication Date: 2017-02-15
DALIAN MEDICAL UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Gastrointestinal reactions are an important reason for patients to delay chemotherapy, which leads to a significant increase in the mortality of cancer patients

Method used

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  • Complex probiotic preparation for reducing 5-hydroxytryptamine side effects after chemotherapy
  • Complex probiotic preparation for reducing 5-hydroxytryptamine side effects after chemotherapy
  • Complex probiotic preparation for reducing 5-hydroxytryptamine side effects after chemotherapy

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Experimental program
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Effect test

specific Embodiment approach

[0026] A compound probiotic preparation, which is formed by mixing the following probiotics according to the following proportions of live bacteria:

[0027] Bifidobacterium breve: Lactobacillus acidophilus: Lactobacillus casei: Streptococcus thermophilus=1:1-3:1-3:1-3, and the total number of viable bacteria in the compound probiotic preparation is 200-800 100 million.

[0028] The application of the compound probiotic preparation as mentioned above in the preparation of medicines for reducing 5-HT.

[0029] Application of the compound probiotic preparation as described above in the preparation of a drug for improving intestinal mucositis.

Embodiment

[0031] SPF grade SD male rats. They were randomly divided into 3 groups, 14 rats in each group, which were blank group, cisplatin + normal saline group (model group: cis-0 means the 0th day of cisplatin treatment, cis-3 means the 3rd day of cisplatin treatment, cis- 6 represents the 6th day of cisplatin treatment), cisplatin + probiotic group (probiotic group: pro-0 represents the 0th day of cisplatin treatment, pro-3 represents the 3rd day of cisplatin treatment, pro-6 represents the cisplatin treatment day 6). The total number of bacteria in the probiotic group rats according to the compound probiotic preparation disclosed by the present invention is 1×10 10 CFU / only probiotics were gavaged, and the blank group and the model group were gavaged with equal volumes of normal saline. The rats were injected with cisplatin 6mg / kg into the tail vein, and the blank group was injected with an equal volume of normal saline. Half of the rats in each group were killed on the 3rd day a...

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Abstract

The invention discloses a complex probiotic preparation for reducing 5-hydroxytryptamine side effects after chemotherapy, the complex probiotic preparation is characterized in that the complex probiotic preparation is prepared by mixing the following probiotics: bifidobacterium breve, lactobacillus acidophilus, lactobacillus casei and Streptococcus thermophilus according to viable number proportion ratio of 1:1-3:1-3:1-3, and the total viable number of the composite probiotic preparation is 20 billion-80 billion; application of the complex probiotic preparation in preparation of drugs for preventing nausea and vomiting after the chemotherapy and application of the complex probiotic preparation in preparation of drugs for improving intestinal mucositis are disclosed.

Description

technical field [0001] The invention relates to a composite probiotic preparation and specific applications of the composite probiotic preparation. Background technique [0002] Chemotherapy is one of the important means of cancer treatment, but there are many adverse reactions after chemotherapy, especially gastrointestinal reactions, including intestinal mucositis and nausea and vomiting. The clinical incidence rate was 40% in patients who received conventional doses of chemotherapy drugs, and intestinal mucositis occurred in almost all patients who received high doses of chemotherapy drugs. Nausea and vomiting is another important gastrointestinal reaction of chemotherapy, which is mainly related to the release of 5-hydroxytryptamine (5-HT) after chemotherapy. The incidence rate is also high, especially almost 100% after injection of cisplatin, which seriously affects patients. quality of life and efficacy of chemotherapy. Gastrointestinal reaction is an important reaso...

Claims

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Application Information

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IPC IPC(8): A61K35/747A61P1/08A61P1/00A61K35/745A61K35/744
CPCA61K35/744A61K35/745A61K35/747A61K2300/00
Inventor 袁杰力董为为李明朱学良吴英韬解傲
Owner DALIAN MEDICAL UNIVERSITY
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