Chromatographic column with high separation effect

A chromatographic column and columnar technology, which is applied in the field of chromatographic columns with high separation effect, can solve problems such as liquid leakage, reduce separation efficiency, and cumbersome series operations, and achieve the effects of reducing preparation steps, improving separation efficiency, and reducing preparation time

Active Publication Date: 2018-12-28
苏州楚博生物技术有限公司
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  • Abstract
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Problems solved by technology

[0003] Usually, multiple purifications are required to obtain the product with the target purity. The common practice is to connect multiple chromatographic columns with different separation levels and types in series, but this method makes the series operation between multi-stage chromatographic columns more difficult. It is cumbersome, and if you are a little careless, it is easy to cause liquid leakage; the too long chromatographic column after series connection requires additional fixtures, which further increases the preparation time for separating compounds and greatly reduces the separation efficiency

Method used

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  • Chromatographic column with high separation effect
  • Chromatographic column with high separation effect

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Embodiment Construction

[0021] The present invention will be further described in detail below in conjunction with the accompanying drawings, and the aforementioned and other objects, features, aspects and advantages of the present invention will become more apparent, so that those skilled in the art can implement them with reference to the description.

[0022] see figure 1 The chromatographic column 100 with high separation effect includes: a housing 110, a cover 120, and a fixed installation sleeve 130, wherein the housing 110 is hollow inside, and a stationary phase is provided inside the housing 110, and the stationary phase includes a columnar stationary phase 150 and a spherical stationary phase group 160 composed of several spherical stationary phases, the spherical stationary phase 160 group is stacked on the columnar stationary phase 150 .

[0023] refer to figure 2 , the upper end surface of the columnar stationary phase 150 is provided with a conical guide groove, the top angle of the g...

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Abstract

The invention discloses a chromatography column with a high separation effect. The chromatography column comprises a shell with a hollow interior, and a stationary phase arranged at the interior of the shell, wherein the stationary phase comprises a columnar stationary phase and a spherical stationary phase set; the spherical stationary phase set is formed by a plurality of spherical stationary phases and is stacked on the columnar stationary phase. The chromatography column has the beneficial effects that while the separation efficiency of compounds can be improved, the length dimension of the chromatography column can be controlled, so that the stability of the chromatography column can be retained, preparation time and preparation steps of separation can be reduced, and the separation efficiency can be improved.

Description

technical field [0001] The invention relates to a chromatographic column, in particular to a chromatographic column with high separation effect. Background technique [0002] Chromatographic columns are used in industrial processes to purify process liquids and to separate substances of interest from process liquids. Impurities are inevitably mixed in the preparation of chemical products such as proteins and drugs, and the purity requirements of proteins and drugs are very high in actual use. Therefore, chromatographic columns are generally used to purify proteins and drugs. A high-purity product is obtained. [0003] Usually, multiple purifications are required to obtain the product of the target purity. The common practice is to connect multiple chromatographic columns of different separation levels and types in series, but this method makes the series operation between multi-stage chromatographic columns easier. It is cumbersome, and if you are a little careless, it is ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D15/22
CPCB01D15/22
Inventor 瞿欢欢朱至放
Owner 苏州楚博生物技术有限公司
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