Synthesis method of medical raw material 5-methoxy-2-methylthio-4-bromopyrimidine

A synthesis method and technology of bromopyrimidine are applied in the field of synthesis of pharmaceutical raw material 5-methoxy-2-methylthio-4-bromopyrimidine, can solve problems such as no reported compound synthesis method, and achieve the effect of simple operation

Inactive Publication Date: 2017-03-22
WUXI QIANHAO BIOPHARMA
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AI Technical Summary

Problems solved by technology

[0002] The synthesis method of 5-methoxy-2-methylthio-4-bromopyrimidine is the starting material for the synthesis of many drugs, especially the important intermediates of many bromopyrimidine compounds. At present, there is no report on the synthesis method of this compound in China

Method used

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Examples

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Embodiment Construction

[0008] The synthetic method of pharmaceutical raw material 5-methoxy-2-methylthio-4-bromopyrimidine of the present invention is specifically as follows:

[0009] Using bromopyrimidine as a raw material, under the action of solvent methanol, ether and PH5-6, under the catalysis of vanadium pentoxide, the temperature is 120°C-170°C to generate 5-methoxy through methylation, oxidation reaction and sulfuration reaction successively -The synthetic method of 2-methylthio-4-bromopyrimidine. The purity of this crude product can meet the general reaction requirements and can be directly put into the reaction.

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Abstract

The invention relates to a synthesis method of a medical raw material 5-methoxy-2-methylthio-4-bromopyrimidine. The synthesis method comprises the following steps: by taking bromopyrimidine as a raw material, performing methylation, oxidation reaction and vulcanization reaction at 120-170 DEG C under the action of solvent methanol, diethyl ether and pH value being 5-6 and the catalysis of vanadium pentoxide, to produce 5-methoxy-2-methylthio-4-bromopyrimidine. The synthesis method of medical intermediate 5-methoxy-2-methylthio-4-bromopyrimidine is simple, safe and efficient to operate, thus being practical in practical production.

Description

technical field [0001] The invention relates to a method for synthesizing 5-methoxy-2-methylthio-4-bromopyrimidine as a medical raw material. Background technique [0002] The synthesis method of 5-methoxy-2-methylthio-4-bromopyrimidine is the starting material for the synthesis of many drugs, especially the important intermediate of many bromopyrimidine compounds. There is no report on the synthesis method of this compound in China at present. Contents of the invention [0003] The object of the present invention is to overcome the above-mentioned disadvantages, and provide a simple, efficient and safe synthetic method of pharmaceutical raw material 5-methoxy-2-methylthio-4-bromopyrimidine. [0004] The purpose of the present invention is achieved like this: [0005] A method for synthesizing 5-methoxy-2-methylthio-4-bromopyrimidine as a medical raw material, using bromopyrimidine as a raw material, under the action of solvent methanol, ether and PH5-6, under the catalys...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): C07D239/56
CPCC07D239/56
Inventor彭海燕
OwnerWUXI QIANHAO BIOPHARMA