Preparation method of terbutaline sulfate solution for inhalation

A solution and preparation technology, applied in the field of medicine, can solve the problems of slow onset of action, long disintegration time, and affecting the full effect of the drug

Inactive Publication Date: 2017-05-17
HANGZHOU BIO SINCERITY PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, the dosage forms of terbutaline sulfate in the domestic and foreign markets include oral and spray inhalation. The oral dosage forms include tablets and dropping pills. Due to the characteristics of the tablet preparation technology, the disintegration time

Method used

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  • Preparation method of terbutaline sulfate solution for inhalation
  • Preparation method of terbutaline sulfate solution for inhalation
  • Preparation method of terbutaline sulfate solution for inhalation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017]

[0018] Process: under heating, add all the above ingredients except sodium hydroxide and hydrochloric acid to dissolve in pure water, adjust the pH of the solution to 3.5 with sodium hydroxide and hydrochloric acid, filter the obtained solution through a sterile filter, and then filter the filtered drug The solution is filled in 2-5ml ampoules, and sterilized by high-pressure steam at 121°C for 15 minutes to obtain the terbutaline sulfate inhalation solution preparation.

Embodiment 2

[0020]

[0021] Process: under heating, add all the above ingredients except sodium hydroxide and hydrochloric acid to dissolve in pure water, adjust the pH of the solution to 3.5 with sodium hydroxide and hydrochloric acid, filter the obtained solution through a sterile filter, and then filter the filtered drug The solution is filled in a colorless and transparent 2-5ml ampoule bottle, and sterilized by high-pressure steam at 121°C for 15 minutes to obtain the terbutaline sulfate inhalation solution preparation.

Embodiment 3

[0023]

[0024] Process: under heating, add all the above ingredients except sodium hydroxide and hydrochloric acid to dissolve in pure water, adjust the pH of the solution to 3.5 with sodium hydroxide and hydrochloric acid, filter the obtained solution through a sterile filter, and then filter the filtered drug The solution is filled in a colorless and transparent 2-5ml ampoule bottle, and sterilized by high-pressure steam at 121°C for 15 minutes to obtain the terbutaline sulfate inhalation solution preparation.

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Abstract

The invention relates to a preparation method of a terbutaline sulfate solution for inhalation. The terbutaline sulfate solution contains a main ingredient, a stabilizer, an iso-osmolar agent, a pH regulator and injection water, and pH value of the terbutaline sulfate solution is 3.0-5.0. The terbutaline sulfate solution has good effect on improving lung functions.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a preparation method of a terbutaline sulfate solution for inhalation for preventing and alleviating respiratory diseases. Background technique [0002] Asthma is a common multiple respiratory disease. Asthma has a large number of patients in my country, and it is relatively common in children. It is a disease that seriously endangers the physical and mental health of the human body and reduces the quality of life. The disease is difficult to be cured, and clinically, conservative treatment is the main method. In recent years, with the aggravation of air quality pollution and the weakening of people's exercise ability, the incidence of asthma is gradually increasing, so the treatment of asthma is urgent. [0003] Terbutaline sulfate is a drug mainly used for the treatment of bronchospasm in bronchial asthma, asthmatic bronchitis and chronic obstructive pulmonary di...

Claims

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Application Information

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IPC IPC(8): A61K9/72A61K31/137A61K9/08A61K47/18A61K47/26A61P11/06
CPCA61K9/008A61K9/08A61K31/137A61K47/183A61K47/26
Inventor 何招燚陆慧傅华锋楼金芳衣丽娜
Owner HANGZHOU BIO SINCERITY PHARMA TECH CO LTD
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