Application of ERK micro-molecular inhibitor in inhibition of drug-resistant lung cancer cells

Abstract

The invention relates to an application of an ERK micro-molecular inhibitor in the preparation of drugs for inhibiting drug-resistant lung cancer cells. The ERK micro-molecular inhibitor inhibits the phosphorylation level of ERK kinase, prevents cell autophagy, and substantially inhibits generation of gefitinib-resistant lung cancer cells in vivo and in vitro, and the ERK micro-molecular inhibitor is TIC10. The lung cancer drug-resistant cell proliferation inhibition molecular mechanism of the ERK micro-molecular inhibitor TIC10 is explicated in the invention, the in-vitro and in-vitro drug-resistant lung cancer cell treatment effect of the ERK micro-molecular inhibitor TIC10 is researched on the basis of the molecular mechanism, and the ERK micro-molecular inhibitor TIC10 can be used for preparing drugs for inhibiting drug-resistant lung cancer cells, solves the problem of treatment failure caused by resistance of lung cancer cells to targeting drugs, reduces the generation of the drug-resistant lung cancer cells, and prolongs the life of lung cancer patients.

Description

technical field [0001] The invention relates to the field of lung cancer treatment, in particular to the application of an ERK small molecule inhibitor in inhibiting the production of drug-resistant lung cancer cells, especially the application in the preparation of drugs for inhibiting the production of drug-resistant lung cancer cells. Background technique [0002] Lung cancer is one of the cancers with the highest incidence and mortality in the world. Most lung cancer patients are already in the advanced stage of cancer when they are diagnosed, and there is a lack of effective treatment. In recent years, targeted drugs have gradually become an effective means of treating lung cancer patients. Currently, one of the commonly used targeted drugs for lung cancer is Tyrosine Kinase Inhibitors (TKIs), which can block the activation of epidermal growth factor receptor (EGFR) kinase in lung cancer cells, thereby inhibiting the proliferation of tumor cells , has a significant ef...

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Problems solved by technology

Autophagy is also induced and activated in a variety of drug-resistant tumor cells, but the role and molecular regulation mechanism of autophagy in the resistance of lung cancer cells to targeted drugs are not very clear, and there is no small molecule inhibitor of ERK. The application report of drug in inhibiting the production of drug-resistant lung cancer cells

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