Application of ERK micro-molecular inhibitor in inhibition of drug-resistant lung cancer cells

A technology of small molecule inhibitors and lung cancer cells, which is applied in the field of preparing drugs to inhibit the production of drug-resistant lung cancer cells, and can solve the problems that there are no reports on the application of ERK small molecule inhibitors, and the mechanism of action and molecular regulation is not very clear. Achieve the effect of reducing the generation of drug-resistant lung cancer cells, inhibiting the generation of drug-resistant tumor cells, and wide application value

Inactive Publication Date: 2017-05-31
SHANGHAI PULMONARY HOSPITAL
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Problems solved by technology

Autophagy is also induced and activated in a variety of drug-resistant tumor cells, but the role and molecular regulation mechanism of autophagy in the resistance of lung cancer cells

Method used

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  • Application of ERK micro-molecular inhibitor in inhibition of drug-resistant lung cancer cells
  • Application of ERK micro-molecular inhibitor in inhibition of drug-resistant lung cancer cells
  • Application of ERK micro-molecular inhibitor in inhibition of drug-resistant lung cancer cells

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Embodiment Construction

[0023] The specific implementation manners of the present invention will be further described below in conjunction with the drawings and examples. The following examples are only used to illustrate the technical solution of the present invention more clearly, but not to limit the protection scope of the present invention. The methods used in the following examples are conventional methods unless otherwise specified.

[0024] The ERK small-molecule inhibitor described in the present invention can inhibit the proliferation and metastasis of various drug-resistant cancer cells, including blood cancer, bone cancer, lymphatic cancer, intestinal cancer, liver cancer, gastric cancer, lung cancer, kidney cancer, esophageal cancer, etc.; ERK Small molecule inhibitors include TIC10, PD098059, U0126, etc.

[0025] The following is just an example to illustrate the effect of ERK small molecule inhibitor TIC10 on inhibiting drug-resistant lung cancer cells.

[0026] 1. Culture, expansion...

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Abstract

The invention relates to an application of an ERK micro-molecular inhibitor in the preparation of drugs for inhibiting drug-resistant lung cancer cells. The ERK micro-molecular inhibitor inhibits the phosphorylation level of ERK kinase, prevents cell autophagy, and substantially inhibits generation of gefitinib-resistant lung cancer cells in vivo and in vitro, and the ERK micro-molecular inhibitor is TIC10. The lung cancer drug-resistant cell proliferation inhibition molecular mechanism of the ERK micro-molecular inhibitor TIC10 is explicated in the invention, the in-vitro and in-vitro drug-resistant lung cancer cell treatment effect of the ERK micro-molecular inhibitor TIC10 is researched on the basis of the molecular mechanism, and the ERK micro-molecular inhibitor TIC10 can be used for preparing drugs for inhibiting drug-resistant lung cancer cells, solves the problem of treatment failure caused by resistance of lung cancer cells to targeting drugs, reduces the generation of the drug-resistant lung cancer cells, and prolongs the life of lung cancer patients.

Description

technical field [0001] The invention relates to the field of lung cancer treatment, in particular to the application of an ERK small molecule inhibitor in inhibiting the production of drug-resistant lung cancer cells, especially the application in the preparation of drugs for inhibiting the production of drug-resistant lung cancer cells. Background technique [0002] Lung cancer is one of the cancers with the highest incidence and mortality in the world. Most lung cancer patients are already in the advanced stage of cancer when they are diagnosed, and there is a lack of effective treatment. In recent years, targeted drugs have gradually become an effective means of treating lung cancer patients. Currently, one of the commonly used targeted drugs for lung cancer is Tyrosine Kinase Inhibitors (TKIs), which can block the activation of epidermal growth factor receptor (EGFR) kinase in lung cancer cells, thereby inhibiting the proliferation of tumor cells , has a significant ef...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K31/519A61P35/00
CPCA61K45/00A61K31/519
Inventor 张帆张鹏
Owner SHANGHAI PULMONARY HOSPITAL
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