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A Synchronous Control Method of Drug Molecules and Its Application

A drug molecule and synchronous control technology, applied in molecular design, drug reference, instrument, etc., can solve problems such as resistance decline, achieve the effects of reducing damage, applying scientific dosage, and reducing side effects

Active Publication Date: 2020-06-30
XUCHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, no matter it is radiotherapy or chemotherapy, it kills healthy cells as well as cancer cells, and the treated patients often have side effects such as vomiting, diarrhea, anemia, and decreased resistance. In order to reduce these side effects, there is an urgent need to develop Model and method for one-to-one control of drug molecules on cancer cells

Method used

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  • A Synchronous Control Method of Drug Molecules and Its Application
  • A Synchronous Control Method of Drug Molecules and Its Application
  • A Synchronous Control Method of Drug Molecules and Its Application

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Embodiment 1

[0030] A synchronous control method of drug molecules provided by the present invention, taking tumor cancer cells as an example, includes the following steps:

[0031] S1. Mathematical models are established for random-walking cancer cells and free-diffusion drug molecules, and the probability concentration equation of cancer cells and the probability concentration equation of drug molecules are obtained.

[0032] We modeled the dynamics of randomly walking cancer cells and freely diffusing drug molecules on the plane, and the results are as follows figure 1 as shown, figure 1 For the motion state diagram of cancer cells and drug molecules on the plane under the premise of no coupling, the probability concentration equation of cancer cells and the probability concentration equation of drug molecules refer to formula (1), and the dynamic interaction process between cancer cells and drug molecules is expressed as It is a macroscopic signal transmission process, and the effecti...

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Abstract

The invention belongs to the technical field of gene information control and discloses a synchronous control method of medicine molecules and application of the synchronous control method. The synchronous control method comprises the following steps: respectively establishing mathematic models of cancer cells moving randomly and medicine molecules diffused freely, and acquiring a cancer cell probability concentration equation and a medicine molecule probability concentration equation; on the basis of a signal transmission phenomenon between the medicine molecules and the cancer cells, finding a definitely existing coupling function of the medicine molecules and the cancer cells, and adding a coupling equation into the established cancer cell probability concentration equation and the medicine molecule probability concentration equation respectively, and plugging the coupling equation into the cancer cell probability concentration equation and the medicine molecule probability concentration equation respectively, thereby obtaining reaction diffusion models for synchronous control by the medicine molecules. By adopting the synchronous control method, one-to-one synchronous control of the medicine molecules to the cancer cells is achieved, and injury of the medicine molecules to healthy cells is reduced.

Description

technical field [0001] The invention belongs to the technical field of gene information control, and in particular relates to a drug molecule synchronous control method and its application. Background technique [0002] Cancer cells are a serious threat to human health and are a difficult problem that the world's medicine is trying to overcome. Cancer cells are diffuse and disordered, and the trajectory of cell proliferation is difficult to control. Therefore, the current treatment models are radiotherapy and chemotherapy. Radiation therapy is a method of treating tumors with radiation. Radiation includes α, β, and γ rays produced by radioactive isotopes and x-rays, electron beams, proton beams and other particle beams produced by various x-ray therapy machines or accelerators. About 70% of cancer patients need radiotherapy in the course of cancer treatment, and about 40% of cancers can be cured with radiotherapy. However, radiotherapy is a local treatment, which is only ef...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G16C20/50G16C20/70G16H70/40
CPCG16C10/00G16C20/50
Inventor 申建伟周灵利
Owner XUCHANG UNIV
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