Acetylated Morinda officinalis water extract, and preparation method and application thereof

A technology for acetylating Morinda officinalis and water extracts, which can be used in pharmaceutical combinations, pharmaceutical formulations, plant raw materials, etc. Significant depressive effect and high antidepressant activity

Inactive Publication Date: 2017-09-15
XINXIANG MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The prior art has reported that the water extract of Morinda officinalis has antidepressant effect (Liang Jianhui, Shu Liang, Luo Zhipu, etc. A preliminary study on the clinical efficacy of the water extract of Morinda officinalis in treating depression. Chinese Journal of Traditional Chinese Medicine. 2002.01. Volume 27 No. 1), but The activity of the water extract is poor, its application is greatly restricted, and commercial production and application cannot be realized

Method used

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  • Acetylated Morinda officinalis water extract, and preparation method and application thereof
  • Acetylated Morinda officinalis water extract, and preparation method and application thereof
  • Acetylated Morinda officinalis water extract, and preparation method and application thereof

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preparation example Construction

[0017] The invention provides a preparation method of acetylated Morinda officinalis water extract, comprising the following steps:

[0018] Take 30g of dried Morinda officinalis water extract, mix with 200mL acetic anhydride and 2g sulfamic acid, react at 10-30°C for 30min, raise the temperature to 60°C-90°C, and react for 20min.

[0019] In the present invention, the preparation method of the water extract of Morinda officinalis is as follows: using water as a solvent to extract Morinda officinalis by reflux. The present invention has no special limitation on the specific parameters of the reflux extraction, and the reflux extraction operation well known to those skilled in the art can be used. Specifically, in the present invention, the solid-liquid ratio of Morinda officinalis and water is preferably 1 : 10, the extraction time per 100g Morinda officinalis is preferably 1.5~3h, more preferably 2h. The present invention has no special limitation on the source of Morinda of...

Embodiment 1

[0028] Take 30g of dried Morinda officinalis water extract, mix with 200mL acetic anhydride and 2g sulfamic acid, react at 15°C for 30min, raise the temperature to 90°C, react for 20min, concentrate and dry.

Embodiment 2

[0030] Take 30g of dried Morinda officinalis water extract, mix with 200mL acetic anhydride and 2g sulfamic acid, react at 25°C for 30min, raise the temperature to 60°C, react for 20min, concentrate and dry.

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Abstract

The invention relates to an acetylated Morinda officinalis water extract, and a preparation method and an application thereof and belongs to the technical field of preparation of antidepressant drugs. The invention providing the acetylated Morinda officinalis water extract, which is prepared through the steps of: mixing 30 g of a dried Morinda officinalis water extract, 200 ml of acetic anhydride and 2 g of amino-sulfonic acid, performing a reaction at 10-30 DEG C for 30 min, increasing temperature to 60-90 DEG C and performing a reaction for 20 min. The acetylated Morinda officinalis water extract is high in antidepressant activity and can be applied to preparation of the antidepressant drugs.

Description

technical field [0001] The invention relates to the technical field of preparation of antidepressant drugs, in particular to an acetylated Morinda officinalis water extract and its preparation method and application. Background technique [0002] Morinda officinalis is a rattan shrub. The root flesh is thick, cylindrical, irregularly and intermittently enlarged, and rosary-shaped. The conventional medicinal functions are anti-fatigue, enhancing immunity, promoting corticosterone secretion, lowering blood pressure and anti-inflammation. [0003] The prior art has reported that the water extract of Morinda officinalis has antidepressant effect (Liang Jianhui, Shu Liang, Luo Zhipu, etc. A preliminary study on the clinical efficacy of the water extract of Morinda officinalis in treating depression. Chinese Journal of Traditional Chinese Medicine. 2002.01. Volume 27 No. 1), but The water extract has poor activity, its application is greatly restricted, and commercial production...

Claims

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Application Information

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IPC IPC(8): A61K36/746A61K47/12A61K47/18A61P25/24
CPCA61K36/746A61K47/12A61K47/183A61K2236/331
Inventor 牛秉轩
Owner XINXIANG MEDICAL UNIV
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