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Method for preparing medicine for treating hypertension by using dendrobium officinale and radish as main materials

A technology of Dendrobium candidum and high blood pressure, which is applied in the field of drug preparation, can solve the problems of insufficient reduction in blood pressure and unsatisfactory curative effect, and achieve the effects of rapid decline, blood pressure and restoration of balance

Active Publication Date: 2020-12-04
HANGZHOU DANHE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still some problems that the reduction of blood pressure is not obvious enough in the near future after taking the medicine, the number of medicines has too many flavors to contain each other or offset the effect, and the medicine composition, extraction, preparation process, etc. have not been systematically optimized, so the curative effect cannot meet the requirements, and it is difficult to be practical in clinical practice. Value

Method used

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  • Method for preparing medicine for treating hypertension by using dendrobium officinale and radish as main materials
  • Method for preparing medicine for treating hypertension by using dendrobium officinale and radish as main materials
  • Method for preparing medicine for treating hypertension by using dendrobium officinale and radish as main materials

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] 2.5 parts of Dendrobium candidum, 2.5 parts of fried radish, 2.5 parts of Ophiopogon japonicus, 2.5 parts of white peony root:

[0036] Take 250g of Dendrobium candidum, 250g of fried radish seed, 250g of Radix Ophiopogon japonicus, and 250g of Radix Paeoniae Alba in accordance with the 2015 edition of "Chinese Pharmacopoeia". Stir-fry radish seeds, Ophiopogon japonicus, and white peony into powder, add 12 times the amount of water, heat and extract for 2 hours, extract twice, and concentrate to 500g. Grind Dendrobium candidum into fine powder, add the above-mentioned fried radish seed, Ophiopogon japonicus, white peony water extract concentrate, stir evenly, make soft material, and then make pills. Tumble dry at 70 degrees. For Example 1 sample. For oral administration, the daily dosage for adults is equivalent to 10g of crude drug (up to 30g).

Embodiment 2

[0038] 10 parts of Dendrobium candidum, 20 parts of fried radish, 10 parts of Ophiopogon japonicus, 10 parts of white peony root:

[0039] Take 200g of Dendrobium officinale, 400g of fried radish seed, 200g of Radix Ophiopogon japonicus and 200g of Radix Paeoniae Alba in accordance with the 2015 edition of "Chinese Pharmacopoeia". Stir-fry radish seeds, Ophiopogon japonicus, and white peony into powder, add 12 times the amount of water, heat and extract for 2 hours, extract twice, and concentrate to 500g. Grind Dendrobium candidum into fine powder, add the above-mentioned fried radish seed, Ophiopogon japonicus, white peony water extract concentrate, stir evenly, make soft material, and then make pills. Tumble dry at 70 degrees. Be embodiment 2 samples. For oral administration, the daily dosage for adults is equivalent to 50g of crude drug (can be as small as 10g).

Embodiment 3

[0041] 15 parts of Dendrobium candidum, 60 parts of fried radish, 15 parts of Ophiopogon japonicus, 15 parts of white peony root:

[0042] Take 142.86g of Dendrobium officinale, 571.43g of fried radish, 142.86g of Radix Ophiopogon japonicus, and 142.86g of Radix Paeoniae Alba, which conform to the 2015 edition of "Chinese Pharmacopoeia". Stir-fry radish seeds, Ophiopogon japonicus, and white peony into powder, add 12 times the amount of water, heat and extract for 2 hours, extract twice, and concentrate to 500g. Grind Dendrobium candidum into fine powder, add the above-mentioned fried radish seed, Ophiopogon japonicus, white peony water extract concentrate, stir evenly, make soft material, and then make pills. Tumble dry at 70 degrees. Be embodiment 3 samples. For oral administration, the daily dosage for adults is equivalent to 105g of crude drug (can be as small as 10g).

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Abstract

The invention relates to a method for preparing drugs for treating hypertension employing dendrobium officinale and semen raphani as main materials. The method comprises the steps of grinding fried semen raphani, radix ophiopogonis and a white peony root into powder, mixing evenly, heating the mixture, extracting and concentrating to obtain a water extract concentrate; grinding dendrobium officinale into powder, adding the powder to the water extract concentrate; and adding auxiliary materials for molding; or grinding the four medicinal materials into powder and then carrying out alcohol extraction: adding 5fold 75% ethanol for extracting at 60 DEG C for 24h, carrying out extraction twice in all and recovering the ethanol; after alcohol extraction, carrying out water extracting treatment on residues, concentrating and merging the alcohol extraction solution and the water extraction solution; and adding the auxiliary materials for molding. The prepared drugs all are suitable for treatment of patients with hypertension, caused by a yin-deficiency syndrome or a yin-deficiency and yang-predominance syndrome, accompanied by restlessness and insomnia, or all are combined with antihypertensive drugs of the Western medicine for treatment to reduce the dosage of the antihypertensive drugs of the Western medicine. Meanwhile, the drugs are suitable for health use of patients with mild hypertension or normal hypertension.

Description

technical field [0001] The invention relates to medicine preparation technology, in particular to a method and application for preparing medicine for treating hypertension by using dendrobium officinale and radish seeds as main materials. Background technique [0002] Hypertension is a common high incidence clinically, which has serious harm to the heart, brain, kidney and other important organs. my country's 2013 "China Cardiovascular Disease Report" estimates that there are currently about 270 million hypertensive patients nationwide. The 2012 and 2013 "China Cardiovascular Disease Report" showed that the mortality rate of cardiovascular disease in my country was 44.1%, ranking first in the spectrum of death diseases. Hypertension is the leading cause of cardiovascular and cerebrovascular diseases. Epidemiological survey results show that the mortality rate of cardiovascular and cerebrovascular diseases in my country is increasing year by year due to high blood pressure....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8984A61P9/12
CPCA61K36/31A61K36/65A61K36/71A61K36/8968A61K36/8984A61K2236/331A61K2236/333A61K2236/53A61K2300/00
Inventor 吴人照
Owner HANGZHOU DANHE PHARM CO LTD
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