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Fructus trichosanthis drop pills, preparation method thereof, and spherical degree and hardness test method of fructus trichosanthis drop pills

A testing method and roundness technology, which is applied in pill delivery, measuring devices, and pharmaceutical formulations, can solve problems affecting the efficacy of Gualou dripping pills, affecting the hardness and roundness of dropping pills, and achieve stable quality of dropping pills Controllable, avoid subjective errors, and objectively evaluate the effect

Active Publication Date: 2017-11-28
WANNAN MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The adhesion of traditional Gualou dripping pills in the production process of the dropping pills directly affects the hardness and roundness of the dropping pills, thereby affecting the efficacy of the Gualou dropping pills

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A preparation method of Gualou dripping pills, comprising the following steps:

[0033] 1) Heat the matrix with a mass ratio of PEG 4000:PEG 6000=1:5 to melt, and maintain the system temperature at 80°C;

[0034] 2) Add the mixed extract of Trichosanthes rind and Trichosanthes seeds with the same quality as the matrix while stirring in step 1), and wait until the mixed extract is completely dissolved and mixed evenly with the matrix;

[0035] 3) Add the medicinal liquid obtained in step 2) into the dripping pill machine, control the dripping temperature to 80°C for the medicinal liquid, 6°C for the condensate, 2mm inner diameter of the dripper, 0.5mm wall thickness, and control the dripping speed to 20 drops / min. The distance is 7cm; drop into simethicone oil, wash and dry the pills to make Gualou dripping pills.

[0036] The preparation method of the mixed extract of described Trichosanthes rind and Trichosanthes seeds is:

[0037] a. Mix Trichosanthes peel and Trich...

Embodiment 2

[0041] A preparation method of Gualou dripping pills, comprising the following steps:

[0042] 1) Heat the matrix with a mass ratio of PEG 4000:PEG 6000=1:3 until it melts, and maintain the system temperature at 75°C;

[0043] 2) Add 1.5 times the mixed extract of Trichosanthes rind and Trichosanthes seeds to step 1) while stirring, until the mixed extract is completely dissolved and mixed evenly with the matrix;

[0044] 3) Add the medicinal liquid obtained in step 2) into the dripping pill machine, control the dripping temperature to 75°C for the medicinal liquid, 8°C for the condensate, the inner diameter of the dripper is 3mm, the wall thickness is 0.8mm, and the dripping speed is controlled to be 40 drops / min. The distance is 13cm; drop into simethicone oil, wash and dry the pills to make Gualou dripping pills.

[0045] The preparation method of the mixed extract of described Trichosanthes rind and Trichosanthes seeds is:

[0046] a. Mix Trichosanthes peel and Trichosan...

Embodiment 3

[0050] A preparation method of Gualou dripping pills, comprising the following steps:

[0051] 1) Heat the matrix with a mass ratio of PEG 4000:PEG 6000=1:7 to melt, and maintain the system temperature at 85°C;

[0052]2) Add 1.9 times the mixed extract of Trichosanthes rind and Trichosanthes seeds to step 1) while stirring, until the mixed extract is completely dissolved and mixed evenly with the matrix;

[0053] 3) Add the medicinal liquid obtained in step 2) into the dripping pill machine, control the dripping temperature to 85°C for the medicinal liquid, 2°C for the condensate, 5mm inner diameter of the dripper, 0.3mm wall thickness, and control the dripping speed to 30 drops / min. The distance is 15cm; drop into simethicone oil, wash and dry the pills to make Gualou dripping pills.

[0054] The preparation method of the mixed extract of described Trichosanthes rind and Trichosanthes seeds is:

[0055] a. Mix Trichosanthes peel and Trichosanthes seeds in a mass ratio of 4...

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Abstract

The invention discloses fructus trichosanthis drop pills, a preparation method thereof, and spherical degree and hardness test method of the fructus trichosanthis drop pills. By taking fructus trichosanthis peel and fructus trichosanthis seed extracts obtained by extracting through a 55%-80% of ethanol solution as medicine components and assisting by PEG 4000 and PEG 6000 substrates, drop pills preparation is prepared; in the preparation process of the drop pills, the ratio of the medicines to the substrates, the ratio of substrate components, condensate liquid types and the dropping speed and the dropping distance in dropping of the drop pills are strictly controlled; and the hardness and the spherical degree of the fructus trichosanthis drop pills are measured through a MS-CAD software assisting method. In the production process of the fructus trichosanthis drop pills, tailing and adhesion are avoided, the quality of the produced drop pills is stable and controllable; and MS-CAD software is selected to assist quantitative measurement of the hardness and the spherical degree of the drop pills, by using the test method for comparing the hardness and the spherical degree of the different drop pills, the personal subjective error can be avoided, and the evaluation result is more objective and more reliable and has better statistical significance.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a Gualou dripping pill and a preparation method thereof, and a method for testing the roundness and hardness of the Gualou dripping pill. Background technique [0002] The use of Gualou for the treatment of chest addiction first appeared in "Synopsis of the Golden Chamber" written by Zhang Zhongjing, a famous doctor in the Han Dynasty. Trichosanthes slices are prepared by mixing 65 parts of Trichosanthes seeds and 35 parts of Trichosanthes peel, extracting and concentrating with water to make extract, adding auxiliary materials, granulating, compressing into tablets, and coating with sugar. It has the effect of broadening the chest and regulating qi, and is used for chest tightness and angina pectoris in coronary heart disease. [0003] Dropping pill preparation is a very common pharmaceutical preparation form, and its processing technology has the advantages of si...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/428A61K9/20A61K47/10G01D21/02A61P9/10
CPCA61K9/2031A61K36/428A61K2236/333A61K2236/39G01D21/02A61K2300/00
Inventor 鄢海燕邹纯才
Owner WANNAN MEDICAL COLLEGE
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