Double nanoparticle drug carrier system containing ApoG2 and AlpcS4 as well as preparation method and application of double nanoparticle drug carrier system

A technology of nano-drug loading and nano-micelle, applied in the field of anti-tumor drug research

Active Publication Date: 2017-12-15
XI AN JIAOTONG UNIV
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  • Abstract
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Problems solved by technology

There is no dual-drug system constructed with AlpcS4 and ApoG2 in the prior art

Method used

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  • Double nanoparticle drug carrier system containing ApoG2 and AlpcS4 as well as preparation method and application of double nanoparticle drug carrier system
  • Double nanoparticle drug carrier system containing ApoG2 and AlpcS4 as well as preparation method and application of double nanoparticle drug carrier system
  • Double nanoparticle drug carrier system containing ApoG2 and AlpcS4 as well as preparation method and application of double nanoparticle drug carrier system

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Embodiment Construction

[0031] The present invention will be further described in detail below in conjunction with specific embodiments, which are explanations of the present invention rather than limitations.

[0032] 1. Preparation of double nano drug loading system:

[0033] Weigh 10mg of F-127 and dissolve in 1ml of absolute ethanol, then dissolve 2.5mg, 2.5mg, and 5mg of ApoG2 in the absolute ethanol solution of F-127 for later use. Weigh 2.5mg, 2.5mg, 5mg of AlpcS4, dissolve in 10ml of deionized water and stir on a magnetic stirrer. Then, the F-127 ethanol solution containing 2.5 mg, 5 mg, and 2.5 mg of ApoG2 was slowly added dropwise to the corresponding deionized water of AlpcS4, and stirred for 24 hours. The specific reaction mode is shown in Table 1. Then it was placed in a dialysis bag for purification for 24 hours, during which the water was changed about 8 times. After the end, it was collected in a 10cm culture plate and freeze-dried at -20°C, and finally freeze-dried to obtain the F-1...

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Abstract

The invention provides a double nanoparticle drug carrier system containing ApoG2 and AlpcS4. The double nanoparticle drug carrier system is prepared from the following components in parts by weight: 1 to 2 parts of ApoG2, 1 to 2 parts of AlpcS4 and 3 to 5 parts of poloxamer, wherein the ApoG2 and the AlpcS4 are encapsulated in the poloxame. According to the double nanoparticle drug carrier system containing the ApoG2 and the AlpcS4, synergistic inactivation of tumor cells by photodynamic therapy of an AlpcS4 photosensitizer and an ApoG2 chemotherapeutic drug can be realized; in addition, the problem of insolubility of the AlpcS4 is effectively solved. The preparation method is simple. The invention further provides a preparation method of the double nanoparticle drug carrier system containing the ApoG2 and the AlpcS4 and application of the double nanoparticle drug carrier system in preparing an antitumor drug.

Description

technical field [0001] The invention relates to the field of antitumor drug research, in particular to a double-nano drug-carrying system containing ApoG2 and AlpcS4, a preparation method and application thereof. Background technique [0002] According to the World Health Organization's 2014 global cancer report, there are 14 million new cases and 8 million deaths worldwide every year. Therefore, malignant tumors seriously endanger human life and health. Among them, gastric cancer is the third most common tumor in my country, with an annual new incidence rate of more than 400,000 and a death rate of more than 300,000, ranking first in the world. According to statistics, more than 40% of new gastric cancers in the world occur in China every year, while the incidence rate in western countries is relatively low, so it has become one of the major diseases that our country must overcome independently. In recent years, the basic research and clinical treatment of gastric cancer ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/107A61K47/10A61P35/00B82Y5/00A61K31/122
CPCA61K9/1075A61K31/122A61K41/0071A61K47/10B82Y5/00A61K2300/00
Inventor 辛静张镇西姚翠萍王兵王晶王斯佳张璐薇
Owner XI AN JIAOTONG UNIV
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