Medicine composition for treating hypertension diseases

A composition and high blood pressure technology, applied in the directions of drug combination, cardiovascular system diseases, pharmaceutical formulations, etc., can solve the problems of increasing the number of people accepted, low content of active ingredients, large dosage, etc., and achieve stable curative effect, clear ingredients, The effect of taking small doses

Inactive Publication Date: 2018-02-27
孙志强
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, due to the low content of active ingredients in Chinese medicine decoction pieces, large dosage, inconvenient, and bitter taste, it is not easy to be accepted by patients. The content of ingredients is increased, the dosage is reduced, it is convenient to take, and the good medicine is no longer bitter, which increases the number of people who accept it

Method used

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  • Medicine composition for treating hypertension diseases

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Experimental program
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Effect test

Embodiment 1

[0058] Prescription: Gastrodia elata total polysaccharide 90g, Uncaria total alkaloids 80g, ghost needle grass total flavonoids 40g, achyranthes bidentata total saponins 60g

[0059] Preparation method: Preparation of total polysaccharides of Gastrodia elata: take Gastrodia elata medicinal material, add 12 times the weight of the medicinal material to extract with water twice, each time for 2 hours, filter, combine the filtrates, concentrate under reduced pressure, remove protein by Sevag method, and dialyze the upper layer of water for 24 hours Remove organic solvents and small molecular substances, concentrate to 1g crude drug / mL, add ethanol to 80% alcohol content, refrigerate and stand for 12 hours, filter, collect precipitates, repeatedly purify the precipitates, add water to fully dissolve, and apply DEAE-52 cellulose The column is eluted with a NaCl gradient of 0.05mol / L to 1.0mol / L, the eluent is concentrated under reduced pressure, and vacuum freeze-dried to obtain the...

Embodiment 2

[0065] Prescription: Gastrodia elata total polysaccharide 90g, Uncaria total alkaloids 80g, ghost needle grass total flavonoids 40g, achyranthes bidentata total saponins 60g

[0066] Preparation method: Preparation of total polysaccharides of Gastrodia elata: take Gastrodia elata medicinal material, add 12 times the weight of the medicinal material to extract with water twice, each time for 2 hours, filter, combine the filtrates, concentrate under reduced pressure, remove protein by Sevag method, and dialyze the upper layer of water for 24 hours Remove organic solvents and small molecular substances, concentrate to 1g crude drug / mL, add ethanol to 80% alcohol content, refrigerate and stand for 12 hours, filter, collect precipitates, repeatedly purify the precipitates, add water to fully dissolve, and apply DEAE-52 cellulose The column is eluted with a NaCl gradient of 0.05mol / L to 1.0mol / L, the eluent is concentrated under reduced pressure, and vacuum freeze-dried to obtain the...

Embodiment 3

[0072] Prescription: Gastrodia elata total polysaccharide 90g, Uncaria total alkaloids 80g, ghost needle grass total flavonoids 40g, achyranthes bidentata total saponins 60g

[0073] Preparation method: Take the total polysaccharides of Gastrodia elata, the total alkaloids of Uncaria, the total flavonoids of Acanthopanax, and the total saponins of Achyranthes bidentata, add 400 g of polyethylene glycol to a total of 500 g, mix well, and press into soft capsules to obtain

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Abstract

The invention discloses a medicine for treating hypertension diseases, belonging to the field of traditional Chinese medicines. The composition is prepared from gastrodia elata total polysaccharides extracted from gastrodia elata, uncaria total alkaloids extracted from uncaria and sticktight total flavones extracted from sticktight in a certain proportion, and conventional pharmaceutical auxiliaries are added to prepare various preparations which can be clinically used for treating hypertension diseases.

Description

technical field [0001] The invention relates to a pharmaceutical composition with the effect of treating hypertension and a preparation method thereof, in particular to a pharmaceutical composition extracted from Gastrodia elata, Achyranthes bidentata, Uncaria, and ghost needle grass, and a preparation method thereof, belonging to the field of traditional Chinese medicine. Background technique [0002] Hypertension refers to an increase in systemic arterial blood pressure (systolic blood pressure and / or diastolic blood pressure) as the main feature (systolic blood pressure ≥ 140 mm Hg, diastolic blood pressure ≥ 90 mm Hg), which may be accompanied by heart, brain, kidney and other organ functions Or clinical syndrome of organic damage. Hypertension is the most common chronic disease and the main risk factor for cardiovascular and cerebrovascular diseases. The blood pressure of a normal person fluctuates within a certain range with changes in the internal and external enviro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8988A61P9/12
CPCA61K36/21A61K36/28A61K36/74A61K36/8988A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2236/55A61K2300/00
Inventor 孙志强
Owner 孙志强
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