Circular composite particle for improving fracture healing

Abstract

The invention provides a circular composite particle for improving fracture healing. The circular composite particle comprises a particle-shaped biological membrane with the ratio of width to height being (2:1)-(1:1), and the particle-shaped biological membrane comprises an elastic layer and a medicine layer from inside to outside; the elastic layer is a dense degradable or absorbable biological membrane, and the medical layer is made of porous loose materials which have good compatibility with human bone substances, are degradable or undegradable, can be absorbed or cannot be absorbed; medicine which has a promotion effect on bone substance healing is further packaged in the medicine layer, the biological micro-structure membrane is of a long-strip-shaped folded structure, the cross section is in a U shape, the inner portion of the composite particle is the elastic layer, and the outer portion of the composite particle is the medicine layer; the ratio of the width to the depth of theU-shaped cross section is 0.5-1.5, and the width is the gap between the surfaces of broken bones which are spliced together after fracture surgery.

Description

technical field [0001] The invention relates to a round composite particle for improving fracture healing. Background technique [0002] At present, it is a frontier field of medical research to use a biocomposite film containing growth factors / stem cells to stick to the fracture line to enhance the speed and quality of fracture healing. There are blood vessels and bone cells distributed on the inner surface of the fracture line (anastomosis line), and whether the healing is good depends on the growth of blood vessels and bone cells in the fracture line. The reason why biofilm sticking to the surface of fracture anastomosis can increase the quality of fracture healing is that on the one hand, the drugs encapsulated in the biofilm can promote the growth of blood vessels and bone cells in the fracture anastomosis, and on the other hand, the biological The membrane isolates external muscles and other human tissues from the fracture anastomotic line, and prevents the reaction o...

AI Technical Summary

Problems solved by technology

[0004] 1. The biocomposite membrane has a relatively large volume area and a small fracture area, and 2 cannot be effectively fitted and fixed together

[0005] 2. The limitations of the current biocomposite membrane materials and manufacturing process lead to performance indicators such as the degradation rate of the biocomposite membrane and the time for the carried growth factors to release the effective drug concentration (the duration of the effective concentration is the key to the healing quality of the fracture line) Unable to meet clinical needs

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