Pharmaceutical composition containing amlexanox and mTOR inhibitor and application of pharmaceutical composition

Abstract

The invention particularly relates to a pharmaceutical composition containing amlexanox and an mTOR inhibitor and an application of the pharmaceutical composition. A surprising activity is displayed through the combined use of the amlexanox and the mTOR inhibitor; therefore, the invention provides the pharmaceutical composition, an interventional medical instrument applied to percutaneous coronaryintervention as well as applications in preparing medicines for preventing and treating angiostegnosis, vasculopathy and main coronary artery disease in patients with ischemic heart disease, acute occlusion or near occlusion in a PTCA operation, pathological change of PTCA significant residual stenosis or postoperative coronary restenosis disease and for preventing and treating benign or malignant tumors, epidermal hyperplasia, psoriasis or prostatic hyperplasia. The amlexanox and the mTOR inhibitor can take a synergistic activity in cell inhibition and cancer treatment; meanwhile, cell agingcan be delayed, and the AS occurrence rate and the thrombus occurrence rate, in comparison with that of independent use of the mTOR inhibitor, can be reduced; and rapid endothelialization of blood vessels can be promoted.

Description

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AI Technical Summary

Benefits of technology

This patented combination uses both an AMPLIX (amictive X-ray absorption) agent with specific properties like being able to reduce calcium levels or block certain enzymes involved in inflammation process while also reducing tumor growth by targeting key molecules associated with this pathway called MTPs (methylthiolarginine).

Problems solved by technology

This patented technical problem addressed in this patent relates to improving the performance and safety profile of certain compounds called triprolinide analogs due to their ability to suppress both nausea/cough responses during experimental treatments aimed at reducing symptoms like painfulness caused by chemotherapies and radiation therapy. These modifications include adding alkali metal salts into medications containing these molecules, modifying them themselves, introducing new ones, exploring novel ways to modify existing methods, developing effective agents based upon these mechanisms, finding out potential applications in medicine preparative processes including gene regulations, stem cell culture, angiogenesis, cardiac disease modelings, and brain function testing.

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