Application of circRNA-PTN to pituitary adenoma biomarkers

A pituitary adenoma and biomarker technology, applied in the application field of natural ribonucleotides, can solve the problems of poor tumor curative effect, limited radiotherapy sensitivity, high recurrence rate, and achieve the effect of stable institutions

Inactive Publication Date: 2018-04-20
THE SECOND HOSPITAL OF DALIAN MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Invasive growth makes it difficult to completely remove the tumor by surgery, and the commonly used drugs bromocriptine and somatostatin have poor curative effects on this type of tumor; invasive growth also limits its sensitivity to radiotherapy, and radiotherapy in the sellar region is easy Damage to important structures such as the normal pituitary gland, hypothalamus, and optic nerve
These factors lead to high postoperative recurrence rate and rapid growth of tumor residual tissue in aggressive pituitary adenomas

Method used

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  • Application of circRNA-PTN to pituitary adenoma biomarkers
  • Application of circRNA-PTN to pituitary adenoma biomarkers
  • Application of circRNA-PTN to pituitary adenoma biomarkers

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Embodiment Construction

[0019] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention. The present invention will be further described below in conjunction with specific embodiment

[0020] 1. Experimental materials, clinical samples: tissue samples of 19 cases of pituitary adenoma (8 cases of invasive pituitary adenoma, 9 cases of non-invasive pituitary adenoma) were provided by the Second Affiliated Hospital of Dalian Medical University.

[0021] Reagents: circRNA-PTN screening primers were synthesized by Invitrogen;

[0022] RNAiso Plus (produ...

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Abstract

The invention discloses application of circRNA-PTN to pituitary adenoma biomarkers, and particularly relates to the technical field of purposes of natural ribonucleotide. The length of the circRNA-PTNis 452bp; the circRNA-PTN is positioned on 137254974 to 137251230 on a 7th chromosome of a human body; PTN is a covering gene of the circRNA; the circRNA-PTN is formed by fourth, fifth and sixth exons of the PTN through trans-splicing; the quantity of the circRNA-PTN from a pituitary adenoma tissue sample of an object is detected; the lower-quantity circRNA-PTN has high pituitary adenoma invasiveness and is relevant to the bad prognosis possibility increase of the object. The purpose of the circRNA-PTN is provided. The circRNA-PTN has the application prospects of becoming the pituitary adenoma biomarkers.

Description

technical field [0001] The present invention relates to the application of circRNA-PTN in pituitary adenoma biomarkers, specifically the technical field of the use of natural ribonucleotides. Background technique [0002] Pituitary adenoma (pituitary tumor for short) is one of the most common intracranial tumors in humans, accounting for about 10%-15% of intracranial tumors. Pituitary tumors are benign tumors histologically, but some pituitary tumors grow aggressively, enveloping or invading the surrounding tissue structure, and it is difficult to completely remove this part of the tumor, which is one of the main reasons for tumor recurrence. According to the biological behavior of pituitary tumors, they can be divided into non-invasive pituitary tumors, invasive pituitary tumors and pituitary carcinomas. Invasive pituitary tumors are between non-invasive pituitary tumors and pituitary carcinomas. Their histological appearance is benign, but their biological characteristics...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/118C12Q2600/158C12Q2600/178
Inventor 张波李欣宇娄佳成王翔郝宇超吕逸竹
Owner THE SECOND HOSPITAL OF DALIAN MEDICAL UNIV
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