Application of circRNA-PTN to pituitary adenoma biomarkers

A pituitary adenoma and biomarker technology, applied in the application field of natural ribonucleotides, can solve the problems of poor tumor curative effect, limited radiotherapy sensitivity, high recurrence rate, and achieve the effect of stable institutions
CN107937549AInactive Publication Date: 2018-04-20THE SECOND HOSPITAL OF DALIAN MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
THE SECOND HOSPITAL OF DALIAN MEDICAL UNIV
Publication Date
2018-04-20
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses application of circRNA-PTN to pituitary adenoma biomarkers, and particularly relates to the technical field of purposes of natural ribonucleotide. The length of the circRNA-PTNis 452bp; the circRNA-PTN is positioned on 137254974 to 137251230 on a 7th chromosome of a human body; PTN is a covering gene of the circRNA; the circRNA-PTN is formed by fourth, fifth and sixth exons of the PTN through trans-splicing; the quantity of the circRNA-PTN from a pituitary adenoma tissue sample of an object is detected; the lower-quantity circRNA-PTN has high pituitary adenoma invasiveness and is relevant to the bad prognosis possibility increase of the object. The purpose of the circRNA-PTN is provided. The circRNA-PTN has the application prospects of becoming the pituitary adenoma biomarkers.
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Description

technical field

[0001] The present invention relates to the application of circRNA-PTN in pituitary adenoma biomarkers, specifically the technical field of the use of natural ribonucleotides. Background technique

[0002] Pituitary adenoma (pituitary tumor for short) is one of the most common intracranial tumors in humans, accounting for about 10%-15% of intracranial tumors. Pituitary tumors are benign tumors histologically, but some pituitary tumors grow aggressively, enveloping or invading the surrounding tissue structure, and it is difficult to completely remove this part of the tumor, which is one of the main reasons for tumor recurrence. According to the biological behavior of pituitary tumors, they can be divided into non-invasive pituitary tumors, invasive pituitary tumors and pituitary carcinomas. Invasive pituitary tumors are between non-invasive pituitary tumors and pituitary carcinomas. Their histological appearance is benign, but their biological characteristics...

Claims

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