Disease-associated gene combination counting method and system

Abstract

The invention discloses a disease-associated gene combination counting method and system. The method comprises computing the significance of every mononucleotide polymorphic site in a gene sequence through a genome-wide association analysis method, wherein the significance presents the degree of association between the mononucleotide polymorphic site and diseases, acquiring the significance of themononucleotide polymorphic sites; according to the significance and a threshold value, screening out the mononucleotide polymorphic sites associated with the diseases to acquire the associated mononucleotide polymorphic sites; through an extreme gradient-based Boosting ensemble learning method, categorizing people corresponding to the associated mononucleotide polymorphic sites into affected onesand non-affected ones and further acquiring associated gene combinations. By combining the genome-wide association analysis method and the gradient-based Boosting ensemble learning method to categorize people corresponding to the associated mononucleotide polymorphic sites into the affected ones and the non-affected ones and further to acquire the associated gene combinations, the disease-associated gene combination counting method can improve the accuracy of acquired disease-associated gene combination results.

Description

technical field [0001] The invention relates to the technical field of biological information, in particular to a statistical method and system for disease-associated gene combinations. Background technique [0002] Currently, researchers use genome-wide association methods to search large numbers of single nucleotide polymorphisms to find genetic mutations that significantly affect phenotype. [0003] Using the genome-wide association method to search a large number of SNPs, the genetic effects of diseases caused by a single nucleotide can be obtained through the statistical test of a single nucleotide, but the inheritance of some diseases is caused by multiple Single nucleotides determine the relationship between multiple single nucleotides and diseases only by using the genome-wide association method. The accuracy of the statistical results is low and the error is large. Contents of the invention [0004] The purpose of the present invention is to provide a statistical...

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Problems solved by technology

[0003] Using the genome-wide association method to search a large number of SNPs, the genetic effects of diseases caused by a single nucleotide can be obtained through the statistical test of a single nucleotide, but the inheritance of some diseases is caused by multiple Determined by a single nucleotide, only the genome-wide association method is used to count the association relationship between multiple single nucleotides and diseases, the accuracy of the statistical results is low, and the error is large

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