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Antitumor drug, antitumor drug for external application and preparation method thereof

An anti-tumor drug and anti-tumor technology, applied in the field of medicine, can solve the problems of difficult to achieve large-scale production, unsatisfactory modification effect, complex modification process, etc., and achieve the effects of wide application range, low cost and simple modification process

Active Publication Date: 2021-09-24
SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the existing anti-tumor biomaterial modification, the cost of the modifier used is high, the modification effect is not ideal, and the application range is narrow; and physical adsorption modification is usually used, the modification process is complicated, the yield is low, and it is difficult to achieve large-scale production

Method used

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  • Antitumor drug, antitumor drug for external application and preparation method thereof
  • Antitumor drug, antitumor drug for external application and preparation method thereof
  • Antitumor drug, antitumor drug for external application and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Preparation of light-cured anti-tumor drugs for external use, specifically including:

[0028] (1) Preparation of photosensitive active TNF-α and photosensitive active IFN-γ.

[0029]Add 100 μg of TNF-α and IFN-γ to 50 μL of 1.5 mg azidobenzoic acid / PBS (pH 7.4, the volume ratio of azidobenzoic acid and PBS is 4:1) solution 10 mL, in an ice bath (4 ℃), under the condition of avoiding light, the magnetic stirring reaction was carried out for 48 hours, so as to synthesize azidophenyl derivatives, TNF-α and IFN-γ with photosensitive activity. After the synthesis, use ultrafiltration centrifuge tubes (Milipore Molecut II, 10KDa) at a speed of 4000rpm / min to centrifuge for 30min to purify the azidophenyl derivatives. After freeze-drying, add PBS solution to dilute the photosensitive active TNF-α and IFN -γ to a concentration of 1 μg / mL to prepare a photosensitive active TNF-α and IFN-γ solution.

[0030] The specific preparation principles of photosensitive active TNF-α an...

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Abstract

The invention discloses an antitumor medicine, an antitumor medicine for external application and a preparation method thereof. The raw materials of the antineoplastic drug include ‑OH, ‑COOH, ‑NH 2 A protein anti-tumor biomaterial of at least one group, a photocoupling agent and a solvent; the photocoupling agent includes an aromatic azide compound; , photocoupling agent and solvent mixed reaction in the system. Among them, the photocoupling agent aromatic azide compound is used as a modifier to modify the above protein anti-tumor biological materials, which has low cost, good modification effect, high yield and wide application range; the synthesized anti-tumor drug contains azidophenyl, With photosensitive activity, it can be photochemically fixed on the medical dressing to form an anti-tumor topical drug. The drug is tightly connected and not easy to fall off. It can continuously send death-inducing signals to tumor cells, prolong the action time of the drug, and improve the therapeutic effect.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an anti-tumor drug, an anti-tumor drug for external application and a preparation method thereof. Background technique [0002] Biomedical materials (also known as biomaterials) are a class of new high-tech materials used to diagnose, treat, repair or replace human tissues and organs or enhance their functions. With the development of society and economy, the injection of new technologies has made biological The medical materials industry continues to develop with an annual growth rate of more than 20%. The successful clinical application of biomaterials has saved the lives of tens of millions of critically ill patients, and has significantly reduced the mortality of cardiovascular diseases, cancer, and other major diseases. It played an important role. The physical and chemical modification of the surface of biomaterials plays an important role in the development of new medic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/54A61K38/21A61K38/19A61P35/00
CPCA61K9/0014A61K38/191A61K38/217A61K47/54A61P35/00A61K2300/00
Inventor 李志斌喻学锋
Owner SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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