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A rapid prediction method and application of the total solid content of Ophiopogon japonicus extract in a preparation process

A technology of total solid content and prediction method, which is applied in the field of rapid prediction of the total solid content of Ophiopogon japonicus extract in the formulation process to achieve the effect of ensuring stability

Active Publication Date: 2020-09-04
SHINEWAY PHARMA GRP LTD
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Problems solved by technology

[0004] Aiming at the problem that the total solid content value of the extract solution determined by the existing Ophiopogon japonicus medicinal material according to the water-soluble or alcohol-soluble extract detection method specified in the Chinese Pharmacopoeia cannot truly reflect the total solid content value of the extract solution in the final production process, the present invention provides a Rapid Prediction Method of Total Solid Content of Ophiopogon japonicus Extract in Preparation Process

Method used

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  • A rapid prediction method and application of the total solid content of Ophiopogon japonicus extract in a preparation process
  • A rapid prediction method and application of the total solid content of Ophiopogon japonicus extract in a preparation process
  • A rapid prediction method and application of the total solid content of Ophiopogon japonicus extract in a preparation process

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Embodiment 1

[0025] A rapid prediction method for the total solid content of Ophiopogon japonicus extract in a preparation process:

[0026] (1) Proposed medicinal solvent extraction method: take about 20g of the test sample, accurately weigh it, put it in a 250-500ml Erlenmeyer flask, add 120ml of 90% ethanol precisely, seal it tightly, weigh it, and let it stand for 1 hour , connect the reflux condenser, heat to boiling, and keep boiling slightly for 4 hours. After cooling down, remove the Erlenmeyer flask, seal it tightly, weigh again, make up for the lost weight with 90% ethanol, shake well, filter with a dry filter, accurately measure 25ml of the filtrate, and place it in a container that has been dried to constant weight. In an evaporating dish, evaporate to dryness on a water bath, dry at 105°C for 3 hours, cool in a desiccator for 30 minutes, and weigh quickly and accurately. The dry product was used to calculate the total solid content (mg / g) of the ethanol extract in Ophiopogon ...

Embodiment 2

[0044] In this embodiment, the predicted value obtained by the rapid prediction equation is compared with the actual detected value in the preparation process.

[0045] (1) The medicinal material extraction method proposed: get about 20g of the test sample, accurately weigh it, put it in a 250-500ml Erlenmeyer flask, add 120ml of 90% ethanol precisely, seal it tightly, weigh it, and let it stand for 1 hour. Connect the reflux condenser, heat to boiling, and keep boiling slightly for 4 hours. After cooling down, remove the Erlenmeyer flask, seal it tightly, weigh again, make up for the lost weight with 90% ethanol, shake well, filter with a dry filter, accurately measure 25ml of the filtrate, and place it in a container that has been dried to constant weight. In an evaporating dish, evaporate to dryness on a water bath, dry at 105°C for 3 hours, cool in a desiccator for 30 minutes, and weigh quickly and accurately. The dry product was used to calculate the total solid content ...

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Abstract

The invention provides a quick forecasting method for a total solid content of a radix ophiopogonis extracting solution in a preparation technology and an application. The method comprises the following steps: a) protocoling a solvent extraction method for radix ophiopogonis medicinal materials; b) performing solvent extraction on the radix ophiopogonis medicinal materials according to the methodprotocoled in the step a), and measuring the total solid content in the solvent extraction solution; c) extracting and refining the radix ophiopogonis medicinal materials according to the specified radix ophiopogonis extracting technology for the preparation containing the radix ophiopogonis medicinal materials, and determining the total solid content of the acquired extraction solution; and d) performing regression equation fitting on the total solid content value measured in the step b) and the total solid content value determined in the step c), thereby acquiring a quick forecasting equation. According to the quick forecasting method provided by the invention, the quick forecasting for the total solid value of the radix ophiopogonis extraction solution in a practical production technology can be realized, the quality control on the medicinal material can be fundamentally realized, the quality of medicinal material meeting quality requirement can be guaranteed and the stability and uniformity of the quality of the end product can be guaranteed.

Description

technical field [0001] The invention relates to the technical field of process analysis, in particular to a rapid prediction method and application of the total solid content of Ophiopogon japonicus extract in a preparation process. Background technique [0002] The extraction of medicinal materials is an important unit operation in the production process of traditional Chinese medicine, and the selection of its process method and process will directly affect the quality and clinical efficacy of traditional Chinese medicine. The extraction of medicinal materials generally includes water decoction, reflux extraction, maceration, percolation, steam distillation and supercritical extraction. Solvent extraction is the most widely used method. It is based on the solubility properties of various active ingredients in medicinal materials, and selects a solvent with high solubility for the target ingredient and low solubility for other ingredients to dissolve the required active ing...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/15
CPCG01N33/15
Inventor 杨琴郝鹏彬孙胜斌姜国志
Owner SHINEWAY PHARMA GRP LTD
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